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Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.
Kotanidis CP, Xie C, Alexander D, Rodrigues JCL, Burnham K, Mentzer A, O'Connor D, Knight J, Siddique M, Lockstone H, Thomas S, Kotronias R, Oikonomou EK, Badi I, Lyasheva M, Shirodaria C, Lumley SF, Constantinides B, Sanderson N, Rodger G, Chau KK, Lodge A, Tsakok M, Gleeson F, Adlam D, Rao P, Indrajeet D, Deshpande A, Bajaj A, Hudson BJ, Srivastava V, Farid S, Krasopoulos G, Sayeed R, Ho LP, Neubauer S, Newby DE, Channon KM, Deanfield J, Antoniades C; COMBAT Consortium; ORFAN investigators. Kotanidis CP, et al. Among authors: lockstone h. Lancet Digit Health. 2022 Oct;4(10):e705-e716. doi: 10.1016/S2589-7500(22)00132-7. Epub 2022 Aug 26. Lancet Digit Health. 2022. PMID: 36038496 Free PMC article.
Transcriptomic Analysis of Inflammatory Cardiomyopathy Identifies Molecular Signatures of Disease and Informs in silico Prediction of a Network-Based Rationale for Therapy.
Singh K, Fang H, Davies G, Wright B, Lockstone H, Williams RO, Ciháková D, Knight JC, Bhattacharya S. Singh K, et al. Among authors: lockstone h. Front Immunol. 2021 Mar 5;12:640837. doi: 10.3389/fimmu.2021.640837. eCollection 2021. Front Immunol. 2021. PMID: 33746983 Free PMC article.
Using de novo assembly to identify structural variation of eight complex immune system gene regions.
Zhang JY, Roberts H, Flores DSC, Cutler AJ, Brown AC, Whalley JP, Mielczarek O, Buck D, Lockstone H, Xella B, Oliver K, Corton C, Betteridge E, Bashford-Rogers R, Knight JC, Todd JA, Band G. Zhang JY, et al. Among authors: lockstone h. PLoS Comput Biol. 2021 Aug 3;17(8):e1009254. doi: 10.1371/journal.pcbi.1009254. eCollection 2021 Aug. PLoS Comput Biol. 2021. PMID: 34343164 Free PMC article.
Short and long-read genome sequencing methodologies for somatic variant detection; genomic analysis of a patient with diffuse large B-cell lymphoma.
Roberts HE, Lopopolo M, Pagnamenta AT, Sharma E, Parkes D, Lonie L, Freeman C, Knight SJL, Lunter G, Dreau H, Lockstone H, Taylor JC, Schuh A, Bowden R, Buck D. Roberts HE, et al. Among authors: lockstone h. Sci Rep. 2021 Mar 19;11(1):6408. doi: 10.1038/s41598-021-85354-8. Sci Rep. 2021. PMID: 33742045 Free PMC article.
miR-3156-5p is downregulated in serum of MEN1 patients and regulates expression of MORF4L2.
Kooblall KG, Stokes VJ, Shariq OA, English KA, Stevenson M, Broxholme J, Wright B, Lockstone HE, Buck D, Grozinsky-Glasberg S, Yates CJ, Thakker RV, Lines KE. Kooblall KG, et al. Among authors: lockstone he. Endocr Relat Cancer. 2022 Aug 4;29(10):557-568. doi: 10.1530/ERC-22-0045. Print 2022 Oct 1. Endocr Relat Cancer. 2022. PMID: 35900839 Free PMC article.
A practical solution for preserving single cells for RNA sequencing.
Attar M, Sharma E, Li S, Bryer C, Cubitt L, Broxholme J, Lockstone H, Kinchen J, Simmons A, Piazza P, Buck D, Livak KJ, Bowden R. Attar M, et al. Among authors: lockstone h. Sci Rep. 2018 Feb 1;8(1):2151. doi: 10.1038/s41598-018-20372-7. Sci Rep. 2018. PMID: 29391536 Free PMC article.
Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.
van Schouwenburg PA, Davenport EE, Kienzler AK, Marwah I, Wright B, Lucas M, Malinauskas T, Martin HC; WGS500 Consortium; Lockstone HE, Cazier JB, Chapel HM, Knight JC, Patel SY. van Schouwenburg PA, et al. Clin Immunol. 2015 Oct;160(2):301-14. doi: 10.1016/j.clim.2015.05.020. Epub 2015 Jun 26. Clin Immunol. 2015. PMID: 26122175 Free PMC article.
58 results