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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.
Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH. Finan B, et al. Among authors: lockie sh. Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218. Sci Transl Med. 2013. PMID: 24174327 Clinical Trial.
Coupled with uncouplers: the curious case of lifespan.
Lockie SH, Müller TD, Tschöp MH. Lockie SH, et al. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E619-20. doi: 10.1152/ajpendo.00060.2009. Epub 2009 Feb 10. Am J Physiol Endocrinol Metab. 2009. PMID: 19208859 Free article. No abstract available.
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH. Day JW, et al. Among authors: lockie sh. Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13. Nat Chem Biol. 2009. PMID: 19597507
Ghrelin-induced adiposity is independent of orexigenic effects.
Perez-Tilve D, Heppner K, Kirchner H, Lockie SH, Woods SC, Smiley DL, Tschöp M, Pfluger P. Perez-Tilve D, et al. Among authors: lockie sh. FASEB J. 2011 Aug;25(8):2814-22. doi: 10.1096/fj.11-183632. Epub 2011 May 4. FASEB J. 2011. PMID: 21543764 Free PMC article.
Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling.
Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker DJ, DiMarchi R, Rahmouni K, Oldfield BJ, Tschöp MH, Perez-Tilve D. Lockie SH, et al. Diabetes. 2012 Nov;61(11):2753-62. doi: 10.2337/db11-1556. Epub 2012 Aug 28. Diabetes. 2012. PMID: 22933116 Free PMC article.
The endocannabinoid system: role in glucose and energy metabolism.
Nogueiras R, Diaz-Arteaga A, Lockie SH, Velásquez DA, Tschop J, López M, Cadwell CC, Diéguez C, Tschöp MH. Nogueiras R, et al. Among authors: lockie sh. Pharmacol Res. 2009 Aug;60(2):93-8. doi: 10.1016/j.phrs.2009.04.004. Epub 2009 Apr 14. Pharmacol Res. 2009. PMID: 19559361 Review.
35 results