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Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors.
Demont EH, Chung CW, Furze RC, Grandi P, Michon AM, Wellaway C, Barrett N, Bridges AM, Craggs PD, Diallo H, Dixon DP, Douault C, Emmons AJ, Jones EJ, Karamshi BV, Locke K, Mitchell DJ, Mouzon BH, Prinjha RK, Roberts AD, Sheppard RJ, Watson RJ, Bamborough P. Demont EH, et al. Among authors: locke k. J Med Chem. 2015 Jul 23;58(14):5649-73. doi: 10.1021/acs.jmedchem.5b00772. Epub 2015 Jul 9. J Med Chem. 2015. PMID: 26155854
A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification.
Bamborough P, Chung CW, Demont EH, Bridges AM, Craggs PD, Dixon DP, Francis P, Furze RC, Grandi P, Jones EJ, Karamshi B, Locke K, Lucas SCC, Michon AM, Mitchell DJ, Pogány P, Prinjha RK, Rau C, Roa AM, Roberts AD, Sheppard RJ, Watson RJ. Bamborough P, et al. Among authors: locke k. J Med Chem. 2019 Aug 22;62(16):7506-7525. doi: 10.1021/acs.jmedchem.9b00673. Epub 2019 Aug 9. J Med Chem. 2019. PMID: 31398032
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM. Lewis HD, et al. Among authors: locke k. Nat Chem Biol. 2015 Mar;11(3):189-91. doi: 10.1038/nchembio.1735. Epub 2015 Jan 26. Nat Chem Biol. 2015. PMID: 25622091 Free PMC article.
Validation of a simple body map to measure widespread pain in urologic chronic pelvic pain syndrome: A MAPP Research Network study.
Clemens JQ, Locke K Jr, Landis JR, Kreder K, Rodriguez LV, Yang CC, Tu FF, Harte SE, Schrepf A, Farrar JT, Sutcliffe S, Naliboff BD, Williams DA, Afari N, Spitznagle T, Taple BJ, Lai HH; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Clemens JQ, et al. Among authors: locke k jr. Neurourol Urodyn. 2024 Mar;43(3):727-737. doi: 10.1002/nau.25400. Epub 2024 Jan 25. Neurourol Urodyn. 2024. PMID: 38270336
Droughts impede water balance recovery from fires in the Western United States.
Ahmad SK, Holmes TR, Kumar SV, Lahmers TM, Liu PW, Nie W, Getirana A, Orland E, Bindlish R, Guzman A, Hain CR, Melton FS, Locke KA, Yang Y. Ahmad SK, et al. Among authors: locke ka. Nat Ecol Evol. 2024 Feb;8(2):229-238. doi: 10.1038/s41559-023-02266-8. Epub 2024 Jan 2. Nat Ecol Evol. 2024. PMID: 38168941
Collective action is needed to build a more just science system.
Rayne A, Arahanga-Doyle H, Cox B, Cox MP, Febria CM, Galla SJ, Hendy SC, Locke K, Matheson A, Pawlik A, Roa T, Sharp EL, Walker LA, Watene K, Wehi PM, Steeves TE. Rayne A, et al. Among authors: locke k. Nat Hum Behav. 2023 Jul;7(7):1034-1037. doi: 10.1038/s41562-023-01635-4. Nat Hum Behav. 2023. PMID: 37291438 No abstract available.
149 results