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Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery.
Wang BZ, Nash TR, Zhang X, Rao J, Abriola L, Kim Y, Zakharov S, Kim M, Luo LJ, Morsink M, Liu B, Lock RI, Fleischer S, Tamargo MA, Bohnen M, Welch CL, Chung WK, Marx SO, Surovtseva YV, Vunjak-Novakovic G, Fine BM. Wang BZ, et al. Among authors: lock ri. Cell Rep Med. 2023 Mar 21;4(3):100976. doi: 10.1016/j.xcrm.2023.100976. Epub 2023 Mar 14. Cell Rep Med. 2023. PMID: 36921598 Free PMC article.
A framework for developing sex-specific engineered heart models.
Lock R, Al Asafen H, Fleischer S, Tamargo M, Zhao Y, Radisic M, Vunjak-Novakovic G. Lock R, et al. Nat Rev Mater. 2022;7(4):295-313. doi: 10.1038/s41578-021-00381-1. Epub 2021 Oct 20. Nat Rev Mater. 2022. PMID: 34691764 Free PMC article. Review.
STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
Zhang X, Wang BZ, Kim M, Nash TR, Liu B, Rao J, Lock R, Tamargo M, Soni RK, Belov J, Li E, Vunjak-Novakovic G, Fine B. Zhang X, et al. Cell Rep. 2022 Aug 16;40(7):111203. doi: 10.1016/j.celrep.2022.111203. Cell Rep. 2022. PMID: 35977512 Free PMC article.
An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury.
Fleischer S, Nash TR, Tamargo MA, Lock RI, Venturini G, Morsink M, Li V, Lamberti MJ, Graney PL, Liberman M, Kim Y, Zhuang RZ, Whitehead J, Friedman RA, Soni RK, Seidman JG, Seidman CE, Geraldino-Pardilla L, Winchester R, Vunjak-Novakovic G. Fleischer S, et al. Among authors: lock ri. bioRxiv [Preprint]. 2024 Mar 12:2024.03.07.583787. doi: 10.1101/2024.03.07.583787. bioRxiv. 2024. PMID: 38559188 Free PMC article. Preprint.