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HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy.
Strappazzon F, Di Rita A, Peschiaroli A, Leoncini PP, Locatelli F, Melino G, Cecconi F. Strappazzon F, et al. Among authors: locatelli f. Cell Death Differ. 2020 Apr;27(4):1155-1168. doi: 10.1038/s41418-019-0404-8. Epub 2019 Aug 21. Cell Death Differ. 2020. PMID: 31434979 Free PMC article.
Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo.
Raimondi L, Ciarapica R, De Salvo M, Verginelli F, Gueguen M, Martini C, De Sio L, Cortese G, Locatelli M, Dang TP, Carlesso N, Miele L, Stifani S, Limon I, Locatelli F, Rota R. Raimondi L, et al. Among authors: locatelli f, locatelli m. Cell Death Differ. 2012 May;19(5):871-81. doi: 10.1038/cdd.2011.171. Epub 2011 Nov 25. Cell Death Differ. 2012. PMID: 22117196 Free PMC article.
The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx).
Ciarapica R, De Salvo M, Carcarino E, Bracaglia G, Adesso L, Leoncini PP, Dall'Agnese A, Walters ZS, Verginelli F, De Sio L, Boldrini R, Inserra A, Bisogno G, Rosolen A, Alaggio R, Ferrari A, Collini P, Locatelli M, Stifani S, Screpanti I, Rutella S, Yu Q, Marquez VE, Shipley J, Valente S, Mai A, Miele L, Puri PL, Locatelli F, Palacios D, Rota R. Ciarapica R, et al. Among authors: locatelli f, locatelli m. Oncogene. 2014 Aug 7;33(32):4173-84. doi: 10.1038/onc.2013.471. Epub 2013 Nov 11. Oncogene. 2014. PMID: 24213577
Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS.
Ciarapica R, Carcarino E, Adesso L, De Salvo M, Bracaglia G, Leoncini PP, Dall'agnese A, Verginelli F, Milano GM, Boldrini R, Inserra A, Stifani S, Screpanti I, Marquez VE, Valente S, Mai A, Puri PL, Locatelli F, Palacios D, Rota R. Ciarapica R, et al. Among authors: locatelli f. BMC Cancer. 2014 Feb 27;14:139. doi: 10.1186/1471-2407-14-139. BMC Cancer. 2014. PMID: 24575771 Free PMC article.
MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment.
Leoncini PP, Bertaina A, Papaioannou D, Flotho C, Masetti R, Bresolin S, Menna G, Santoro N, Zecca M, Basso G, Nigita G, Veneziano D, Pagotto S, D'Ovidio K, Rota R, Dorrance A, Croce CM, Niemeyer C, Locatelli F, Garzon R. Leoncini PP, et al. Among authors: locatelli f. Oncotarget. 2016 Aug 23;7(34):55395-55408. doi: 10.18632/oncotarget.10577. Oncotarget. 2016. PMID: 27447965 Free PMC article.
Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.
Gnani D, Romito I, Artuso S, Chierici M, De Stefanis C, Panera N, Crudele A, Ceccarelli S, Carcarino E, D'Oria V, Porru M, Giorda E, Ferrari K, Miele L, Villa E, Balsano C, Pasini D, Furlanello C, Locatelli F, Nobili V, Rota R, Leonetti C, Alisi A. Gnani D, et al. Among authors: locatelli f. Cell Death Differ. 2017 May;24(5):889-902. doi: 10.1038/cdd.2017.34. Epub 2017 Mar 24. Cell Death Differ. 2017. PMID: 28338656 Free PMC article.
AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis.
Becher J, Simula L, Volpe E, Procaccini C, La Rocca C, D'Acunzo P, Cianfanelli V, Strappazzon F, Caruana I, Nazio F, Weber G, Gigantino V, Botti G, Ciccosanti F, Borsellino G, Campello S, Mandolesi G, De Bardi M, Fimia GM, D'Amelio M, Ruffini F, Furlan R, Centonze D, Martino G, Braghetta P, Chrisam M, Bonaldo P, Matarese G, Locatelli F, Battistini L, Cecconi F. Becher J, et al. Among authors: locatelli f. Dev Cell. 2018 Dec 3;47(5):592-607.e6. doi: 10.1016/j.devcel.2018.11.010. Dev Cell. 2018. PMID: 30513302 Free article.
Reversible induction of mitophagy by an optogenetic bimodular system.
D'Acunzo P, Strappazzon F, Caruana I, Meneghetti G, Di Rita A, Simula L, Weber G, Del Bufalo F, Dalla Valle L, Campello S, Locatelli F, Cecconi F. D'Acunzo P, et al. Among authors: locatelli f. Nat Commun. 2019 Apr 4;10(1):1533. doi: 10.1038/s41467-019-09487-1. Nat Commun. 2019. PMID: 30948710 Free PMC article.
2,179 results