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Kinases as targets for Parkinson's disease: from genetics to therapy.
Vancraenenbroeck R, Lobbestael E, Maeyer MD, Baekelandt V, Taymans JM. Vancraenenbroeck R, et al. Among authors: lobbestael e. CNS Neurol Disord Drug Targets. 2011 Sep 1;10(6):724-40. doi: 10.2174/187152711797247858. CNS Neurol Disord Drug Targets. 2011. PMID: 21838679 Review.
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Beilina A, Rudenko IN, Kaganovich A, Civiero L, Chau H, Kalia SK, Kalia LV, Lobbestael E, Chia R, Ndukwe K, Ding J, Nalls MA; International Parkinson’s Disease Genomics Consortium; North American Brain Expression Consortium; Olszewski M, Hauser DN, Kumaran R, Lozano AM, Baekelandt V, Greene LE, Taymans JM, Greggio E, Cookson MR. Beilina A, et al. Among authors: lobbestael e. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2626-31. doi: 10.1073/pnas.1318306111. Epub 2014 Feb 7. Proc Natl Acad Sci U S A. 2014. PMID: 24510904 Free PMC article.
LRRK2 Phosphorylation: Behind the Scenes.
De Wit T, Baekelandt V, Lobbestael E. De Wit T, et al. Among authors: lobbestael e. Neuroscientist. 2018 Oct;24(5):486-500. doi: 10.1177/1073858418756309. Epub 2018 Jan 31. Neuroscientist. 2018. PMID: 29385885 Review.
Phosphorylation of LRRK2: from kinase to substrate.
Lobbestael E, Baekelandt V, Taymans JM. Lobbestael E, et al. Biochem Soc Trans. 2012 Oct;40(5):1102-10. doi: 10.1042/BST20120128. Biochem Soc Trans. 2012. PMID: 22988873 Review.
Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.
Krumova P, Reyniers L, Meyer M, Lobbestael E, Stauffer D, Gerrits B, Muller L, Hoving S, Kaupmann K, Voshol J, Fabbro D, Bauer A, Rovelli G, Taymans JM, Bouwmeester T, Baekelandt V. Krumova P, et al. Among authors: lobbestael e. FASEB J. 2015 Jul;29(7):2980-92. doi: 10.1096/fj.14-262329. Epub 2015 Apr 8. FASEB J. 2015. PMID: 25854701
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
Civiero L, Cirnaru MD, Beilina A, Rodella U, Russo I, Belluzzi E, Lobbestael E, Reyniers L, Hondhamuni G, Lewis PA, Van den Haute C, Baekelandt V, Bandopadhyay R, Bubacco L, Piccoli G, Cookson MR, Taymans JM, Greggio E. Civiero L, et al. Among authors: lobbestael e. J Neurochem. 2015 Dec;135(6):1242-56. doi: 10.1111/jnc.13369. Epub 2015 Oct 19. J Neurochem. 2015. PMID: 26375402 Free PMC article.
38 results