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A Role for the Autophagic Receptor, SQSTM1/p62, in Trafficking NF-κB/RelA to Nucleolar Aggresomes.
Mol Cancer Res. 2021 Feb;19(2):274-287. doi: 10.1158/1541-7786.MCR-20-0336. Epub 2020 Oct 23.
Mol Cancer Res. 2021.
PMID: 33097627
Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.
Chen J, Lobb IT, Morin P, Novo SM, Simpson J, Kennerknecht K, von Kriegsheim A, Batchelor EE, Oakley F, Stark LA.
Chen J, et al. Among authors: lobb it.
Nucleic Acids Res. 2018 Jul 6;46(12):6188-6205. doi: 10.1093/nar/gky455.
Nucleic Acids Res. 2018.
PMID: 29873780
Free PMC article.
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SynLeGG: analysis and visualization of multiomics data for discovery of cancer 'Achilles Heels' and gene function relationships.
Wappett M, Harris A, Lubbock ALR, Lobb I, McDade S, Overton IM.
Wappett M, et al.
Nucleic Acids Res. 2021 Jul 2;49(W1):W613-W618. doi: 10.1093/nar/gkab338.
Nucleic Acids Res. 2021.
PMID: 33997893
Free PMC article.
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USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF.
Jurisic A, Sung PJ, Wappett M, Daubriac J, Lobb IT, Kung WW, Crawford N, Page N, Cassidy E, Feutren-Burton S, Rountree JSS, Helm MD, O'Dowd CR, Kennedy RD, Gavory G, Cranston AN, Longley DB, Jacq X, Harrison T.
Jurisic A, et al. Among authors: lobb it.
Clin Transl Med. 2024 Apr;14(4):e1648. doi: 10.1002/ctm2.1648.
Clin Transl Med. 2024.
PMID: 38602256
Free PMC article.
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The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes.
Ortmann BM, Burrows N, Lobb IT, Arnaiz E, Wit N, Bailey PSJ, Jordon LH, Lombardi O, Peñalver A, McCaffrey J, Seear R, Mole DR, Ratcliffe PJ, Maxwell PH, Nathan JA.
Ortmann BM, et al. Among authors: lobb it.
Nat Genet. 2021 Jul;53(7):1022-1035. doi: 10.1038/s41588-021-00887-y. Epub 2021 Jun 21.
Nat Genet. 2021.
PMID: 34155378
Free PMC article.
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MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA.
Stefanovic-Barrett S, et al. Among authors: lobb it.
EMBO Rep. 2018 May;19(5):e45603. doi: 10.15252/embr.201745603. Epub 2018 Mar 8.
EMBO Rep. 2018.
PMID: 29519897
Free PMC article.
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Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.
Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT, Freisinger P, Dodd RB, Dougan G, Lehner PJ, Frezza C, Nathan JA.
Burr SP, et al. Among authors: lobb it.
Cell Metab. 2016 Nov 8;24(5):740-752. doi: 10.1016/j.cmet.2016.09.015. Epub 2016 Oct 27.
Cell Metab. 2016.
PMID: 27923773
Free PMC article.
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The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains.
Grice GL, Lobb IT, Weekes MP, Gygi SP, Antrobus R, Nathan JA.
Grice GL, et al. Among authors: lobb it.
Cell Rep. 2015 Jul 28;12(4):545-53. doi: 10.1016/j.celrep.2015.06.061. Epub 2015 Jul 16.
Cell Rep. 2015.
PMID: 26190103
Free PMC article.
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