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Non-Fibrillar Oligomeric Amyloid-β within Synapses.
Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R, Walsh DM, Hyman BT, Spires-Jones TL. Pickett EK, et al. Among authors: lleo a. J Alzheimers Dis. 2016 May 30;53(3):787-800. doi: 10.3233/JAD-160007. J Alzheimers Dis. 2016. PMID: 27258414
Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.
Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Berezovska O, et al. Among authors: lleo a. J Neurosci. 2005 Mar 16;25(11):3009-17. doi: 10.1523/JNEUROSCI.0364-05.2005. J Neurosci. 2005. PMID: 15772361 Free PMC article.
We show that FAD-linked missense mutations located near the N and C termini, in the mid-region of PS1, and the exon 9 deletion mutation all change the spatial relationship between PS1 N and C termini in a similar way, increasing proximity of the two epitopes. This effect i …
We show that FAD-linked missense mutations located near the N and C termini, in the mid-region of PS1, and the exon 9 deletion mutation all …
Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.
Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A. Guardia-Laguarta C, et al. Among authors: lleo a. J Neurochem. 2009 Jul;110(1):220-30. doi: 10.1111/j.1471-4159.2009.06126.x. Epub 2009 Apr 27. J Neurochem. 2009. PMID: 19457132 Free PMC article.
558 results