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An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.
Brown HA, Williams CAC, Zhou H, Rios-Szwed D, Fernandez-Alonso R, Mansoor S, McMulkin L, Toth R, Gourlay R, Peltier J, Dieguez-Martinez N, Trost M, Lizcano JM, Stavridis MP, Findlay GM. Brown HA, et al. Among authors: lizcano jm. Biochem J. 2021 Dec 10;478(23):4119-4136. doi: 10.1042/BCJ20210646. Biochem J. 2021. PMID: 34780645 Free PMC article.
Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.
Erazo T, Moreno A, Ruiz-Babot G, Rodríguez-Asiain A, Morrice NA, Espadamala J, Bayascas JR, Gómez N, Lizcano JM. Erazo T, et al. Among authors: lizcano jm. Mol Cell Biol. 2013 Apr;33(8):1671-86. doi: 10.1128/MCB.01246-12. Epub 2013 Feb 19. Mol Cell Biol. 2013. PMID: 23428871 Free PMC article.
Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS. Wang J, et al. Among authors: lizcano jm. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31. ACS Chem Biol. 2018. PMID: 30102854 Free PMC article.
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Muñoz-Guardiola P, Casas J, Megías-Roda E, Solé S, Perez-Montoyo H, Yeste-Velasco M, Erazo T, Diéguez-Martínez N, Espinosa-Gil S, Muñoz-Pinedo C, Yoldi G, Abad JL, Segura MF, Moran T, Romeo M, Bosch-Barrera J, Oaknin A, Alfón J, Domènech C, Fabriàs G, Velasco G, Lizcano JM. Muñoz-Guardiola P, et al. Among authors: lizcano jm. Autophagy. 2021 Jun;17(6):1349-1366. doi: 10.1080/15548627.2020.1761651. Epub 2020 May 25. Autophagy. 2021. PMID: 32397857 Free PMC article.
ERK5 Inhibition Induces Autophagy-Mediated Cancer Cell Death by Activating ER Stress.
Gámez-García A, Bolinaga-Ayala I, Yoldi G, Espinosa-Gil S, Diéguez-Martínez N, Megías-Roda E, Muñoz-Guardiola P, Lizcano JM. Gámez-García A, et al. Among authors: lizcano jm. Front Cell Dev Biol. 2021 Nov 4;9:742049. doi: 10.3389/fcell.2021.742049. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34805151 Free PMC article.
80 results