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The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase.
Erazo T, Lorente M, López-Plana A, Muñoz-Guardiola P, Fernández-Nogueira P, García-Martínez JA, Bragado P, Fuster G, Salazar M, Espadaler J, Hernández-Losa J, Bayascas JR, Cortal M, Vidal L, Gascón P, Gómez-Ferreria M, Alfón J, Velasco G, Domènech C, Lizcano JM. Erazo T, et al. Among authors: lizcano jm. Clin Cancer Res. 2016 May 15;22(10):2508-19. doi: 10.1158/1078-0432.CCR-15-1808. Epub 2015 Dec 15. Clin Cancer Res. 2016. PMID: 26671995 Free article. Clinical Trial.
Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.
Erazo T, Moreno A, Ruiz-Babot G, Rodríguez-Asiain A, Morrice NA, Espadamala J, Bayascas JR, Gómez N, Lizcano JM. Erazo T, et al. Among authors: lizcano jm. Mol Cell Biol. 2013 Apr;33(8):1671-86. doi: 10.1128/MCB.01246-12. Epub 2013 Feb 19. Mol Cell Biol. 2013. PMID: 23428871 Free PMC article.
Oncosuppressive functions of tribbles pseudokinase 3.
Salazar M, Lorente M, Orea-Soufi A, Dávila D, Erazo T, Lizcano J, Carracedo A, Kiss-Toth E, Velasco G. Salazar M, et al. Biochem Soc Trans. 2015 Oct;43(5):1122-6. doi: 10.1042/BST20150124. Biochem Soc Trans. 2015. PMID: 26517935 Review.
Correction for Zurashvili et al., Interaction of PDK1 with Phosphoinositides Is Essential for Neuronal Differentiation but Dispensable for Neuronal Survival.
Zurashvili T, Cordón-Barris L, Ruiz-Babot G, Zhou X, Lizcano JM, Gómez N, Giménez-Llort L, Bayascas JR. Zurashvili T, et al. Among authors: lizcano jm. Mol Cell Biol. 2016 May 31;36(12):1818. doi: 10.1128/MCB.00085-16. Print 2016 Jun 15. Mol Cell Biol. 2016. PMID: 27247313 Free PMC article. No abstract available.
Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors.
Cordón-Barris L, Pascual-Guiral S, Yang S, Giménez-Llort L, Lope-Piedrafita S, Niemeyer C, Claro E, Lizcano JM, Bayascas JR. Cordón-Barris L, et al. Among authors: lizcano jm. Mol Cell Biol. 2016 Nov 14;36(23):2967-2982. doi: 10.1128/MCB.00230-16. Print 2016 Dec 1. Mol Cell Biol. 2016. PMID: 27644329 Free PMC article.
ERK5 and Cell Proliferation: Nuclear Localization Is What Matters.
Gomez N, Erazo T, Lizcano JM. Gomez N, et al. Among authors: lizcano jm. Front Cell Dev Biol. 2016 Sep 22;4:105. doi: 10.3389/fcell.2016.00105. eCollection 2016. Front Cell Dev Biol. 2016. PMID: 27713878 Free PMC article. Review.
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