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TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma.
Schaettler MO, Desai R, Wang AZ, Livingstone AJ, Kobayashi DK, Coxon AT, Bowman-Kirigin JA, Liu CJ, Li M, Bender DE, White MJ, Kranz DM, Johanns TM, Dunn GP. Schaettler MO, et al. Among authors: livingstone aj. J Immunother Cancer. 2023 Feb;11(2):e006121. doi: 10.1136/jitc-2022-006121. J Immunother Cancer. 2023. PMID: 36808076 Free PMC article.
The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain.
Bowman-Kirigin JA, Desai R, Saunders BT, Wang AZ, Schaettler MO, Liu CJ, Livingstone AJ, Kobayashi DK, Durai V, Kretzer NM, Zipfel GJ, Leuthardt EC, Osbun JW, Chicoine MR, Kim AH, Murphy KM, Johanns TM, Zinselmeyer BH, Dunn GP. Bowman-Kirigin JA, et al. Among authors: livingstone aj. Cancer Immunol Res. 2023 Jan 3;11(1):20-37. doi: 10.1158/2326-6066.CIR-22-0098. Cancer Immunol Res. 2023. PMID: 36409838 Free PMC article.
Glioblastoma-infiltrating CD8+ T cells are predominantly a clonally expanded GZMK+ effector population.
Wang AZ, Mashimo BL, Schaettler MO, Sherpa ND, Leavitt LA, Livingstone AJ, Khan SM, Li M, Anzaldua-Campos MI, Bradley JD, Leuthardt EC, Kim AH, Dowling JL, Chicoine MR, Jones PS, Choi BD, Cahill DP, Carter BS, Petti AA, Johanns TM, Dunn GP. Wang AZ, et al. Among authors: livingstone aj. Cancer Discov. 2024 Feb 28. doi: 10.1158/2159-8290.CD-23-0913. Online ahead of print. Cancer Discov. 2024. PMID: 38416133
Integrating multisector molecular characterization into personalized peptide vaccine design for patients with newly diagnosed glioblastoma.
Johanns TM, Garfinkle EAR, Miller KE, Livingstone AJ, Roberts KF, Rao Venkata LP, Dowling JL, Chicoine MR, Dacey RG, Zipfel GJ, Kim AH, Mardis ER, Dunn GP. Johanns TM, et al. Among authors: livingstone aj. Clin Cancer Res. 2024 Apr 19. doi: 10.1158/1078-0432.CCR-23-3077. Online ahead of print. Clin Cancer Res. 2024. PMID: 38639919