Liu Z - Search Results

1

Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.

Wang G, Liu Z, Chen T, Wang Z, Yang H, Zheng M, Ren J, Tian G, Yang X, Li L, Li J, Suo J, Zhang R, Jiang X, Terrett NK, Shen J, Xu Y, Jiang H. Wang G, et al. Among authors: liu z. J Med Chem. 2012 Dec 13;55(23):10540-50. doi: 10.1021/jm301159y. Epub 2012 Nov 19. J Med Chem. 2012. PMID: 23137303

2

Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.

Wang Z, Jiang X, Zhang X, Tian G, Yang R, Wu J, Zou X, Liu Z, Yang X, Wu C, Shi J, Li J, Suo J, Wang Y, Zhang R, Xu Z, Gong X, He Y, Zhu W, Aisa HA, Jiang H, Xu Y, Shen J. Wang Z, et al. Among authors: liu z. J Med Chem. 2019 May 23;62(10):4979-4990. doi: 10.1021/acs.jmedchem.9b00123. Epub 2019 May 8. J Med Chem. 2019. PMID: 31021628

3

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.

Duan H, Zheng J, Lai Q, Liu Z, Tian G, Wang Z, Li J, Shen J. Duan H, et al. Among authors: liu z. Bioorg Med Chem Lett. 2009 May 15;19(10):2777-9. doi: 10.1016/j.bmcl.2009.03.125. Epub 2009 Mar 28. Bioorg Med Chem Lett. 2009. PMID: 19375311

4

Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors.

Xu Z, Liu Z, Chen T, Chen T, Wang Z, Tian G, Shi J, Wang X, Lu Y, Yan X, Wang G, Jiang H, Chen K, Wang S, Xu Y, Shen J, Zhu W. Xu Z, et al. Among authors: liu z. J Med Chem. 2011 Aug 11;54(15):5607-11. doi: 10.1021/jm200644r. Epub 2011 Jul 14. J Med Chem. 2011. PMID: 21714539

5

Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.

Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J. Gong X, et al. Among authors: liu z. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. Epub 2013 Jun 29. Bioorg Med Chem Lett. 2013. PMID: 23867165

6

4-Acetyl-2,3,4,5-tetra-hydro-1H-1,4-benzodiazepine.

Zhao QJ, Liu Z, Zheng J, Shen JS. Zhao QJ, et al. Among authors: liu z. Acta Crystallogr Sect E Struct Rep Online. 2008 May 3;64(Pt 6):o969. doi: 10.1107/S1600536808007927. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21202698 Free PMC article.

7

A new diketopyrrolopyrrole-based probe for sensitive and selective detection of sulfite in aqueous solution.

Yang X, Cui Y, Li Y, Zheng L, Xie L, Ning R, Liu Z, Lu J, Zhang G, Liu C, Zhang G. Yang X, et al. Among authors: liu z, liu c. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 25;137:1055-60. doi: 10.1016/j.saa.2014.08.144. Epub 2014 Oct 4. Spectrochim Acta A Mol Biomol Spectrosc. 2015. PMID: 25291502

8

Synergistic antitumor effect of AAV-mediated TRAIL expression combined with cisplatin on head and neck squamous cell carcinoma.

Jiang M, Liu Z, Xiang Y, Ma H, Liu S, Liu Y, Zheng D. Jiang M, et al. Among authors: liu z, liu y, liu s. BMC Cancer. 2011 Feb 3;11:54. doi: 10.1186/1471-2407-11-54. BMC Cancer. 2011. PMID: 21291526 Free PMC article.

9

Refolding of inclusion body proteins from E. coli.

Su Z, Lu D, Liu Z. Su Z, et al. Among authors: liu z. Methods Biochem Anal. 2011;54:319-38. doi: 10.1002/9780470939932.ch13. Methods Biochem Anal. 2011. PMID: 21954784 Review. No abstract available.

10

A lipase-responsive vehicle using amphipathic polymer synthesized with the lipase as catalyst.

Ge J, Lu D, Yang C, Liu Z. Ge J, et al. Among authors: liu z. Macromol Rapid Commun. 2011 Mar 16;32(6):546-50. doi: 10.1002/marc.201000746. Epub 2011 Jan 21. Macromol Rapid Commun. 2011. PMID: 21433214

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