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Tissue-specific modifier alleles determine Mertk loss-of-function traits.
Akalu YT, Mercau ME, Ansems M, Hughes LD, Nevin J, Alberto EJ, Liu XN, He LZ, Alvarado D, Keler T, Kong Y, Philbrick WM, Bosenberg M, Finnemann SC, Iavarone A, Lasorella A, Rothlin CV, Ghosh S. Akalu YT, et al. Among authors: liu xn. Elife. 2022 Aug 15;11:e80530. doi: 10.7554/eLife.80530. Elife. 2022. PMID: 35969037 Free PMC article.
Seipin is required for converting nascent to mature lipid droplets.
Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV. Wang H, et al. Among authors: liu xn. Elife. 2016 Aug 26;5:e16582. doi: 10.7554/eLife.16582. Elife. 2016. PMID: 27564575 Free PMC article.
Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos.
Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG. Jesinkey SR, et al. Cell Rep. 2019 Jul 16;28(3):759-772.e10. doi: 10.1016/j.celrep.2019.06.058. Cell Rep. 2019. PMID: 31315053 Free PMC article.
Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake.
Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, López-Giráldez F, DeVries SG, Li H, Ruiz DM, Wang KY, Sayal BS, González Zapata S, Dann P, Brown SN, Hirabara S, Vatner DF, Goedeke L, Philbrick W, Shulman GI, Bogan JS. Habtemichael EN, et al. Nat Metab. 2021 Mar;3(3):378-393. doi: 10.1038/s42255-021-00359-x. Epub 2021 Mar 8. Nat Metab. 2021. PMID: 33686286 Free PMC article.
Chronic mTOR activation induces a degradative smooth muscle cell phenotype.
Li G, Wang M, Caulk AW, Cilfone NA, Gujja S, Qin L, Chen PY, Chen Z, Yousef S, Jiao Y, He C, Jiang B, Korneva A, Bersi MR, Wang G, Liu X, Mehta S, Geirsson A, Gulcher JR, Chittenden TW, Simons M, Humphrey JD, Tellides G. Li G, et al. J Clin Invest. 2020 Mar 2;130(3):1233-1251. doi: 10.1172/JCI131048. J Clin Invest. 2020. PMID: 32039915 Free PMC article.
Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis.
Zhang X, Ramírez CM, Aryal B, Madrigal-Matute J, Liu X, Diaz A, Torrecilla-Parra M, Suárez Y, Cuervo AM, Sessa WC, Fernández-Hernando C. Zhang X, et al. Arterioscler Thromb Vasc Biol. 2020 Jun;40(6):1510-1522. doi: 10.1161/ATVBAHA.120.314291. Epub 2020 Apr 30. Arterioscler Thromb Vasc Biol. 2020. PMID: 32349535 Free PMC article.
305 results