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cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity.
Liu H, Moura-Alves P, Pei G, Mollenkopf HJ, Hurwitz R, Wu X, Wang F, Liu S, Ma M, Fei Y, Zhu C, Koehler AB, Oberbeck-Mueller D, Hahnke K, Klemm M, Guhlich-Bornhof U, Ge B, Tuukkanen A, Kolbe M, Dorhoi A, Kaufmann SH. Liu H, et al. Among authors: liu s. EMBO Rep. 2019 Apr;20(4):e46293. doi: 10.15252/embr.201846293. Epub 2019 Mar 14. EMBO Rep. 2019. PMID: 30872316 Free PMC article.
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SHE, Chen C, Mao Z, Ge B. Liu H, et al. Among authors: liu z, liu s, liu f. Nature. 2018 Nov;563(7729):131-136. doi: 10.1038/s41586-018-0629-6. Epub 2018 Oct 24. Nature. 2018. PMID: 30356214
Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS.
Wang F, Zhao M, Chang B, Zhou Y, Wu X, Ma M, Liu S, Cao Y, Zheng M, Dang Y, Xu J, Chen L, Liu T, Tang F, Ren Y, Xu Z, Mao Z, Huang K, Luo M, Li J, Liu H, Ge B. Wang F, et al. Among authors: liu h, liu s, liu t. Mol Cell. 2022 Jun 2;82(11):2032-2049.e7. doi: 10.1016/j.molcel.2022.03.034. Epub 2022 Apr 22. Mol Cell. 2022. PMID: 35460603 Free article.
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