Liu L - Search Results

1

Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance.

Liu B, Yu X, Liu L, Wang L, Wang J, Huang Q, Xu Z, Luo C, Lou L, Huang W, Yang W. Liu B, et al. Among authors: liu l. J Med Chem. 2023 Feb 23;66(4):2550-2565. doi: 10.1021/acs.jmedchem.2c01424. Epub 2023 Feb 2. J Med Chem. 2023. PMID: 36728755

2

Topoisomerase II inhibitors from the roots of Stellera chamaejasme L.

Liu LP, Han K, Chen W, Zhang YY, Tong LJ, Peng T, Xie H, Ding J, Wang HB. Liu LP, et al. Bioorg Med Chem. 2014 Aug 1;22(15):4198-203. doi: 10.1016/j.bmc.2014.05.042. Epub 2014 May 29. Bioorg Med Chem. 2014. PMID: 24931277

3

Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine.

Fu T, Liu L, Yang QL, Wang Y, Xu P, Zhang L, Liu S, Dai Q, Ji Q, Xu GL, He C, Luo C, Zhang L. Fu T, et al. Among authors: liu l, liu s. Chem Sci. 2019 Jun 27;10(31):7407-7417. doi: 10.1039/c9sc02807b. eCollection 2019 Aug 21. Chem Sci. 2019. PMID: 31489163 Free PMC article.

4

Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors.

Lin T, Li J, Liu L, Li Y, Jiang H, Chen K, Xu P, Luo C, Zhou B. Lin T, et al. Among authors: liu l. Eur J Med Chem. 2021 Apr 5;215:113281. doi: 10.1016/j.ejmech.2021.113281. Epub 2021 Feb 11. Eur J Med Chem. 2021. PMID: 33611192

5

Discovery and characterization of a novel glucose-6-phosphate dehydrogenase (G6PD) inhibitor via high-throughput screening.

Luo Z, Du D, Liu Y, Lu T, Liu L, Jiang H, Chen K, Shan C, Luo C. Luo Z, et al. Among authors: liu y, liu l. Bioorg Med Chem Lett. 2021 May 15;40:127905. doi: 10.1016/j.bmcl.2021.127905. Epub 2021 Mar 6. Bioorg Med Chem Lett. 2021. PMID: 33689874

6

Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3.

Lu T, Li Y, Lu W, Spitters T, Fang X, Wang J, Cai S, Gao J, Zhou Y, Duan Z, Xiong H, Liu L, Li Q, Jiang H, Chen K, Zhou H, Lin H, Feng H, Zhou B, Antos CL, Luo C. Lu T, et al. Among authors: liu l. Acta Pharm Sin B. 2021 Oct;11(10):3206-3219. doi: 10.1016/j.apsb.2021.04.015. Epub 2021 May 1. Acta Pharm Sin B. 2021. PMID: 34729310 Free PMC article.

7

Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).

Liu L, Zhu R, Li J, Pei Y, Wang S, Xu P, Wang M, Wen Y, Zhang H, Du D, Ding H, Jiang H, Chen K, Zhou B, Yu L, Luo C. Liu L, et al. J Med Chem. 2022 Feb 10;65(3):2174-2190. doi: 10.1021/acs.jmedchem.1c01686. Epub 2022 Jan 28. J Med Chem. 2022. PMID: 35089030

8

Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis.

Fu R, Zu SJ, Liu YJ, Li JC, Dang WZ, Liao LP, Liu LP, Chen PY, Huang HM, Wu KH, Zhou B, Pan Q, Luo C, Zhang YY, Li GM. Fu R, et al. Bioengineered. 2022 Apr;13(4):10914-10930. doi: 10.1080/21655979.2022.2066756. Bioengineered. 2022. PMID: 35499161 Free PMC article.

9

Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer.

Li J, Liu T, Song Y, Wang M, Liu L, Zhu H, Li Q, Lin J, Jiang H, Chen K, Zhao K, Wang M, Zhou H, Lin H, Luo C. Li J, et al. Among authors: liu l, liu t. J Med Chem. 2022 Aug 25;65(16):11034-11057. doi: 10.1021/acs.jmedchem.2c00257. Epub 2022 Aug 4. J Med Chem. 2022. PMID: 35925880

10

A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6.

Liao L, Dang W, Lin T, Yu J, Liu T, Li W, Xiao S, Feng L, Huang J, Fu R, Li J, Liu L, Wang M, Tao H, Jiang H, Chen K, Diao X, Zhou B, Shen X, Luo C. Liao L, et al. Among authors: liu l, liu t. Acta Pharm Sin B. 2022 Nov;12(11):4180-4192. doi: 10.1016/j.apsb.2022.05.012. Epub 2022 May 14. Acta Pharm Sin B. 2022. PMID: 36386479 Free PMC article.

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