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Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.
Lalaoui N, Boyden SE, Oda H, Wood GM, Stone DL, Chau D, Liu L, Stoffels M, Kratina T, Lawlor KE, Zaal KJM, Hoffmann PM, Etemadi N, Shield-Artin K, Biben C, Tsai WL, Blake MD, Kuehn HS, Yang D, Anderton H, Silke N, Wachsmuth L, Zheng L, Moura NS, Beck DB, Gutierrez-Cruz G, Ombrello AK, Pinto-Patarroyo GP, Kueh AJ, Herold MJ, Hall C, Wang H, Chae JJ, Dmitrieva NI, McKenzie M, Light A, Barham BK, Jones A, Romeo TM, Zhou Q, Aksentijevich I, Mullikin JC, Gross AJ, Shum AK, Hawkins ED, Masters SL, Lenardo MJ, Boehm M, Rosenzweig SD, Pasparakis M, Voss AK, Gadina M, Kastner DL, Silke J. Lalaoui N, et al. Among authors: liu l. Nature. 2020 Jan;577(7788):103-108. doi: 10.1038/s41586-019-1828-5. Epub 2019 Dec 11. Nature. 2020. PMID: 31827281 Free PMC article.
25 years of research put RIPK1 in the clinic.
Liu L, Lalaoui N. Liu L, et al. Semin Cell Dev Biol. 2021 Jan;109:86-95. doi: 10.1016/j.semcdb.2020.08.007. Epub 2020 Sep 13. Semin Cell Dev Biol. 2021. PMID: 32938551 Review.
Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death.
Liu L, Sandow JJ, Leslie Pedrioli DM, Samson AL, Silke N, Kratina T, Ambrose RL, Doerflinger M, Hu Z, Morrish E, Chau D, Kueh AJ, Fitzibbon C, Pellegrini M, Pearson JS, Hottiger MO, Webb AI, Lalaoui N, Silke J. Liu L, et al. Sci Adv. 2022 May 13;8(19):eabh2332. doi: 10.1126/sciadv.abh2332. Epub 2022 May 11. Sci Adv. 2022. PMID: 35544574 Free PMC article.
Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death.
Frank D, Garnish SE, Sandow JJ, Weir A, Liu L, Clayer E, Meza L, Rashidi M, Cobbold SA, Scutts SR, Doerflinger M, Anderton H, Lawlor KE, Lalaoui N, Kueh AJ, Eng VV, Ambrose RL, Herold MJ, Samson AL, Feltham R, Murphy JM, Ebert G, Pearson JS, Vince JE. Frank D, et al. Among authors: liu l. iScience. 2022 Jun 17;25(7):104632. doi: 10.1016/j.isci.2022.104632. eCollection 2022 Jul 15. iScience. 2022. PMID: 35800780 Free PMC article.
Targeting triple-negative breast cancers with the Smac-mimetic birinapant.
Lalaoui N, Merino D, Giner G, Vaillant F, Chau D, Liu L, Kratina T, Pal B, Whittle JR, Etemadi N, Berthelet J, Gräsel J, Hall C, Ritchie ME, Ernst M, Smyth GK, Vaux DL, Visvader JE, Lindeman GJ, Silke J. Lalaoui N, et al. Among authors: liu l. Cell Death Differ. 2020 Oct;27(10):2768-2780. doi: 10.1038/s41418-020-0541-0. Epub 2020 Apr 27. Cell Death Differ. 2020. PMID: 32341449 Free PMC article.
Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN.1 and other variants.
Piepenbrink MS, Khalil AM, Chang A, Mostafa A, Basu M, Sarkar S, Panjwani S, Ha YH, Ma Y, Ye C, Wang Q, Green TJ, Kizziah JL, Erdmann NB, Goepfert PA, Liu L, Ho DD, Martinez-Sobrido L, Walter MR, Kobie JJ. Piepenbrink MS, et al. Among authors: liu l. bioRxiv [Preprint]. 2024 Apr 29:2024.04.27.591446. doi: 10.1101/2024.04.27.591446. bioRxiv. 2024. PMID: 38746414 Free PMC article. Preprint.
Identification of Fibrinogen as a Plasma Protein Binding Partner for Lecanemab Biosimilar IgG: Implications for Alzheimer's Disease Therapy.
Bellier JP, Román Viera AM, Christiano C, Anzai JAU, Moreno S, Campbell EC, Godwin L, Li A, Chen AY, Alam S, Saba A, Yoo HB, Yang HS, Chhatwal JP, Selkoe DJ, Liu L. Bellier JP, et al. Among authors: liu l. bioRxiv [Preprint]. 2024 May 1:2024.05.01.591892. doi: 10.1101/2024.05.01.591892. bioRxiv. 2024. PMID: 38746192 Free PMC article. Preprint.
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