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IRF-1 promotes renal fibrosis by downregulation of Klotho.
Li Y, Liu Y, Huang Y, Yang K, Xiao T, Xiong J, Wang K, Liu C, He T, Yu Y, Han W, Wang Y, Bi X, Zhang J, Huang Y, Zhang B, Zhao J. Li Y, et al. Among authors: liu y, liu c. FASEB J. 2020 Mar;34(3):4415-4429. doi: 10.1096/fj.201902446R. Epub 2020 Jan 21. FASEB J. 2020. PMID: 31965641
Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cells.
Li Y, Liu Y, Wang K, Huang Y, Han W, Xiong J, Yang K, Liu M, Xiao T, Liu C, He T, Bi X, Zhang J, Zhang B, Zhao J. Li Y, et al. Among authors: liu y, liu m, liu c. BMC Mol Cell Biol. 2020 Jun 22;21(1):45. doi: 10.1186/s12860-020-00292-z. BMC Mol Cell Biol. 2020. PMID: 32571212 Free PMC article.
IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4.
Huang Y, Wang S, Zhou J, Liu Y, Du C, Yang K, Bi X, Liu M, Han W, Wang K, Xiong J, Wang S, Wang Y, Nie L, Liu C, Zhang D, Gu J, Zeng C, Zhao J. Huang Y, et al. Among authors: liu y, liu m, liu c. Nat Commun. 2020 Sep 16;11(1):4664. doi: 10.1038/s41467-020-18519-0. Nat Commun. 2020. PMID: 32938919 Free PMC article.
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