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Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Kim D, Herdeis L, Rudolph D, Zhao Y, Böttcher J, Vides A, Ayala-Santos CI, Pourfarjam Y, Cuevas-Navarro A, Xue JY, Mantoulidis A, Bröker J, Wunberg T, Schaaf O, Popow J, Wolkerstorfer B, Kropatsch KG, Qu R, de Stanchina E, Sang B, Li C, McConnell DB, Kraut N, Lito P. Kim D, et al. Among authors: lito p. Nature. 2023 Jul;619(7968):160-166. doi: 10.1038/s41586-023-06123-3. Epub 2023 May 31. Nature. 2023. PMID: 37258666 Free PMC article.
An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer.
Xue Y, Martelotto L, Baslan T, Vides A, Solomon M, Mai TT, Chaudhary N, Riely GJ, Li BT, Scott K, Cechhi F, Stierner U, Chadalavada K, de Stanchina E, Schwartz S, Hembrough T, Nanjangud G, Berger MF, Nilsson J, Lowe SW, Reis-Filho JS, Rosen N, Lito P. Xue Y, et al. Among authors: lito p. Nat Med. 2017 Aug;23(8):929-937. doi: 10.1038/nm.4369. Epub 2017 Jul 17. Nat Med. 2017. PMID: 28714990 Free PMC article.
A treatment strategy for KRAS-driven tumors.
Mai TT, Lito P. Mai TT, et al. Among authors: lito p. Nat Med. 2018 Jul;24(7):902-904. doi: 10.1038/s41591-018-0111-x. Nat Med. 2018. PMID: 29988139 No abstract available.
Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition.
Xue JY, Zhao Y, Aronowitz J, Mai TT, Vides A, Qeriqi B, Kim D, Li C, de Stanchina E, Mazutis L, Risso D, Lito P. Xue JY, et al. Among authors: lito p. Nature. 2020 Jan;577(7790):421-425. doi: 10.1038/s41586-019-1884-x. Epub 2020 Jan 8. Nature. 2020. PMID: 31915379 Free PMC article.
Quest for Clinically Effective RAF Dimer Inhibitors.
Xue JY, Lito P. Xue JY, et al. Among authors: lito p. J Clin Oncol. 2020 Jul 1;38(19):2197-2200. doi: 10.1200/JCO.20.00401. Epub 2020 May 20. J Clin Oncol. 2020. PMID: 32432945 No abstract available.
42 results