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Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, Cowen LE. Caplan T, et al. Cell Chem Biol. 2020 Mar 19;27(3):269-282.e5. doi: 10.1016/j.chembiol.2019.12.008. Epub 2020 Jan 7. Cell Chem Biol. 2020. PMID: 31924499 Free PMC article.
Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen.
O'Meara TR, O'Meara MJ, Polvi EJ, Pourhaghighi MR, Liston SD, Lin ZY, Veri AO, Emili A, Gingras AC, Cowen LE. O'Meara TR, et al. Among authors: liston sd. PLoS Biol. 2019 Jul 8;17(7):e3000358. doi: 10.1371/journal.pbio.3000358. eCollection 2019 Jul. PLoS Biol. 2019. PMID: 31283755 Free PMC article.
Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets.
Fu C, Zhang X, Veri AO, Iyer KR, Lash E, Xue A, Yan H, Revie NM, Wong C, Lin ZY, Polvi EJ, Liston SD, VanderSluis B, Hou J, Yashiroda Y, Gingras AC, Boone C, O'Meara TR, O'Meara MJ, Noble S, Robbins N, Myers CL, Cowen LE. Fu C, et al. Among authors: liston sd. Nat Commun. 2021 Nov 11;12(1):6497. doi: 10.1038/s41467-021-26850-3. Nat Commun. 2021. PMID: 34764269 Free PMC article.
16 results