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SF2312 is a natural phosphonate inhibitor of enolase.
Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR 4th, Sun D, Prasad BAB, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL. Leonard PG, et al. Among authors: link tm. Nat Chem Biol. 2016 Dec;12(12):1053-1058. doi: 10.1038/nchembio.2195. Epub 2016 Oct 10. Nat Chem Biol. 2016. PMID: 27723749 Free PMC article.
Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity.
Mandal PK, Morlacchi P, Knight JM, Link TM, Lee GR 4th, Nurieva R, Singh D, Dhanik A, Kavraki L, Corry DB, Ladbury JE, McMurray JS. Mandal PK, et al. Among authors: link tm. J Med Chem. 2015 Nov 25;58(22):8970-84. doi: 10.1021/acs.jmedchem.5b01321. Epub 2015 Nov 9. J Med Chem. 2015. PMID: 26506089 Free PMC article.
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells.
Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong SD, Link TM, Gallup TD, Qie Y, Li X, Dong S, Schrank BR, Grippin AJ, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong AC, Tainer JA, Jiang W, Kim BYS. Lee D, et al. Among authors: link tm. Nat Biomed Eng. 2024 Apr 19. doi: 10.1038/s41551-024-01194-7. Online ahead of print. Nat Biomed Eng. 2024. PMID: 38641710
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
Brosey CA, Houl JH, Katsonis P, Balapiti-Modarage LPF, Bommagani S, Arvai A, Moiani D, Bacolla A, Link T, Warden LS, Lichtarge O, Jones DE, Ahmed Z, Tainer JA. Brosey CA, et al. Prog Biophys Mol Biol. 2021 Aug;163:171-186. doi: 10.1016/j.pbiomolbio.2021.02.002. Epub 2021 Feb 23. Prog Biophys Mol Biol. 2021. PMID: 33636189 Free PMC article.
601 results