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Oxidation potentials of N-modified derivatives of the analgesic flupirtine linked to potassium KV 7 channel opening activity but not hepatocyte toxicity.
Lemmerhirt CJ, Rombach M, Bodtke A, Bednarski PJ, Link A. Lemmerhirt CJ, et al. Among authors: link a. ChemMedChem. 2015 Feb;10(2):368-79. doi: 10.1002/cmdc.201402442. Epub 2014 Nov 12. ChemMedChem. 2015. PMID: 25392984
KV 7.2/3 (KCNQ2/3) opening activity was determined by an established assay with HEK293 cells overexpressing these channels. A link was found between the oxidation potentials of the compounds and their EC50 values for potassium channel opening activity. ...
KV 7.2/3 (KCNQ2/3) opening activity was determined by an established assay with HEK293 cells overexpressing these channels. A link …
Substituted tetrazoles as multipurpose screening compounds.
Rüger N, Fassauer GM, Bock C, Emmrich T, Bodtke A, Link A. Rüger N, et al. Among authors: link a. Mol Divers. 2017 Feb;21(1):9-27. doi: 10.1007/s11030-016-9711-x. Epub 2016 Dec 27. Mol Divers. 2017. PMID: 28028725
714 results