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Exosomes released by imatinib‑resistant K562 cells contain specific membrane markers, IFITM3, CD146 and CD36 and increase the survival of imatinib‑sensitive cells in the presence of imatinib.
Hrdinova T, Toman O, Dresler J, Klimentova J, Salovska B, Pajer P, Bartos O, Polivkova V, Linhartova J, Machova Polakova K, Kabickova H, Brodska B, Krijt M, Zivny J, Vyoral D, Petrak J. Hrdinova T, et al. Among authors: linhartova j. Int J Oncol. 2021 Feb;58(2):238-250. doi: 10.3892/ijo.2020.5163. Epub 2020 Dec 23. Int J Oncol. 2021. PMID: 33491750
Next-generation deep sequencing improves detection of BCR-ABL1 kinase domain mutations emerging under tyrosine kinase inhibitor treatment of chronic myeloid leukemia patients in chronic phase.
Machova Polakova K, Kulvait V, Benesova A, Linhartova J, Klamova H, Jaruskova M, de Benedittis C, Haferlach T, Baccarani M, Martinelli G, Stopka T, Ernst T, Hochhaus A, Kohlmann A, Soverini S. Machova Polakova K, et al. Among authors: linhartova j. J Cancer Res Clin Oncol. 2015 May;141(5):887-99. doi: 10.1007/s00432-014-1845-6. Epub 2014 Nov 4. J Cancer Res Clin Oncol. 2015. PMID: 25367136
Somatic Mutations in Oncogenes Are in Chronic Myeloid Leukemia Acquired De Novo via Deregulated Base-Excision Repair and Alternative Non-Homologous End Joining.
Curik N, Polivkova V, Burda P, Koblihova J, Laznicka A, Kalina T, Kanderova V, Brezinova J, Ransdorfova S, Karasova D, Rejlova K, Bakardjieva M, Kuzilkova D, Kundrat D, Linhartova J, Klamova H, Salek C, Klener P, Hrusak O, Machova Polakova K. Curik N, et al. Among authors: linhartova j. Front Oncol. 2021 Sep 20;11:744373. doi: 10.3389/fonc.2021.744373. eCollection 2021. Front Oncol. 2021. PMID: 34616685 Free PMC article.
In chronic myeloid leukemia patients on second-line tyrosine kinase inhibitor therapy, deep sequencing of BCR-ABL1 at the time of warning may allow sensitive detection of emerging drug-resistant mutants.
Soverini S, De Benedittis C, Castagnetti F, Gugliotta G, Mancini M, Bavaro L, Machova Polakova K, Linhartova J, Iurlo A, Russo D, Pane F, Saglio G, Rosti G, Cavo M, Baccarani M, Martinelli G. Soverini S, et al. Among authors: linhartova j. BMC Cancer. 2016 Aug 2;16:572. doi: 10.1186/s12885-016-2635-0. BMC Cancer. 2016. PMID: 27485109 Free PMC article.
Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology.
Hovorkova L, Zaliova M, Venn NC, Bleckmann K, Trkova M, Potuckova E, Vaskova M, Linhartova J, Machova Polakova K, Fronkova E, Muskovic W, Giles JE, Shaw PJ, Cario G, Sutton R, Stary J, Trka J, Zuna J. Hovorkova L, et al. Among authors: linhartova j. Blood. 2017 May 18;129(20):2771-2781. doi: 10.1182/blood-2016-11-749978. Epub 2017 Mar 22. Blood. 2017. PMID: 28331056 Free article.
Next-generation sequencing for sensitive detection of BCR-ABL1 mutations relevant to tyrosine kinase inhibitor choice in imatinib-resistant patients.
Soverini S, De Benedittis C, Polakova KM, Linhartova J, Castagnetti F, Gugliotta G, Papayannidis C, Mancini M, Klamova H, Salvucci M, Crugnola M, Iurlo A, Albano F, Russo D, Rosti G, Cavo M, Baccarani M, Martinelli G. Soverini S, et al. Among authors: linhartova j. Oncotarget. 2016 Apr 19;7(16):21982-90. doi: 10.18632/oncotarget.8010. Oncotarget. 2016. PMID: 26980736 Free PMC article.
All hematopoietic stem cells engraft in submyeloablatively irradiated mice.
Forgacova K, Savvulidi F, Sefc L, Linhartova J, Necas E. Forgacova K, et al. Among authors: linhartova j. Biol Blood Marrow Transplant. 2013 May;19(5):713-9. doi: 10.1016/j.bbmt.2013.02.012. Epub 2013 Feb 16. Biol Blood Marrow Transplant. 2013. PMID: 23422843 Free article.
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