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A Recombinant Chimeric Protein-Based Vaccine Containing T-Cell Epitopes from Amastigote Proteins and Combined with Distinct Adjuvants, Induces Immunogenicity and Protection against Leishmania infantum Infection.
Lage DP, Vale DL, Linhares FP, Freitas CS, Machado AS, Cardoso JMO, de Oliveira D, Galvani NC, de Oliveira MP, Oliveira-da-Silva JA, Ramos FF, Tavares GSV, Ludolf F, Bandeira RS, Pereira IAG, Chávez-Fumagalli MA, Roatt BM, Machado-de-Ávila RA, Christodoulides M, Coelho EAF, Martins VT. Lage DP, et al. Among authors: linhares fp. Vaccines (Basel). 2022 Jul 19;10(7):1146. doi: 10.3390/vaccines10071146. Vaccines (Basel). 2022. PMID: 35891310 Free PMC article.
A recombinant Leishmania amastigote-specific protein, rLiHyG, with adjuvants, protects against infection with Leishmania infantum.
Machado AS, Lage DP, Vale DL, Freitas CS, Linhares FP, Cardoso JMO, Pereira IAG, Ramos FF, Tavares GSV, Ludolf F, Oliveira-da-Silva JA, Bandeira RS, Simões AC, Duarte MC, Oliveira JS, Christodoulides M, Chávez-Fumagalli MA, Roatt BM, Martins VT, Coelho EAF. Machado AS, et al. Among authors: linhares fp. Acta Trop. 2022 Jun;230:106412. doi: 10.1016/j.actatropica.2022.106412. Epub 2022 Mar 16. Acta Trop. 2022. PMID: 35305943
Recombinant guanosine-5'-triphosphate (GTP)-binding protein associated with Poloxamer 407-based polymeric micelles protects against Leishmania infantum infection.
Lage DP, Machado AS, Vale DL, Freitas CS, Linhares FP, Cardoso JMO, Pereira IAG, Ramos FF, Tavares GSV, Ludolf F, Oliveira-da-Silva JA, Bandeira RS, Silva AM, Simões LC, Reis TAR, Oliveira JS, Christodoulides M, Chávez-Fumagalli MA, Roatt BM, Martins VT, Coelho EAF. Lage DP, et al. Among authors: linhares fp. Cytokine. 2022 May;153:155865. doi: 10.1016/j.cyto.2022.155865. Epub 2022 Mar 23. Cytokine. 2022. PMID: 35339043
Leishmania LiHyC protein is immunogenic and induces protection against visceral leishmaniasis.
Machado AS, Lage DP, Vale DL, Freitas CS, Linhares FP, Cardoso JMO, Oliveira-da-Silva JA, Pereira IAG, Ramos FF, Tavares GSV, Ludolf F, Bandeira RS, Maia LGN, Menezes-Souza D, Duarte MC, Chávez-Fumagalli MA, Roatt BM, Christodoulides M, Martins VT, Coelho EAF. Machado AS, et al. Among authors: linhares fp. Parasite Immunol. 2022 Aug;44(8):e12921. doi: 10.1111/pim.12921. Epub 2022 Apr 27. Parasite Immunol. 2022. PMID: 35437797
Recombinant endonuclease III protein from Leishmania infantum associated with Th1-type adjuvants is immunogenic and induces protection against visceral leishmaniasis.
Lage DP, Machado AS, Freitas CS, Vale DL, Linhares FP, Cardoso JMO, Oliveira-da-Silva JA, Ramos FF, Pereira IAG, Ludolf F, Tavares GSV, Bandeira RS, Oliveira JS, Menezes-Souza D, Duarte MC, Galdino AS, Christodoulides M, Chávez-Fumagalli MA, Roatt BM, Martins VT, Coelho EAF. Lage DP, et al. Among authors: linhares fp. Mol Immunol. 2023 Mar;155:79-90. doi: 10.1016/j.molimm.2023.01.011. Epub 2023 Jan 31. Mol Immunol. 2023. PMID: 36731193