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CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle.
Negoita F, Addinsall AB, Hellberg K, Bringas CF, Hafen PS, Sermersheim TJ, Agerholm M, Lewis CTA, Ahwazi D, Ling NXY, Larsen JK, Deshmukh AS, Hossain MA, Oakhill JS, Ochala J, Brault JJ, Sankar U, Drewry DH, Scott JW, Witczak CA, Sakamoto K. Negoita F, et al. Among authors: ling nxy. Mol Metab. 2023 Sep;75:101761. doi: 10.1016/j.molmet.2023.101761. Epub 2023 Jun 26. Mol Metab. 2023. PMID: 37380024 Free PMC article.
Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism.
Hoffman NJ, Whitfield J, Janzen NR, Belhaj MR, Galic S, Murray-Segal L, Smiles WJ, Ling NXY, Dite TA, Scott JW, Oakhill JS, Brink R, Kemp BE, Hawley JA. Hoffman NJ, et al. Among authors: ling nxy. Mol Metab. 2020 Nov;41:101048. doi: 10.1016/j.molmet.2020.101048. Epub 2020 Jun 29. Mol Metab. 2020. PMID: 32610071 Free PMC article.
mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress.
Ling NXY, Kaczmarek A, Hoque A, Davie E, Ngoei KRW, Morrison KR, Smiles WJ, Forte GM, Wang T, Lie S, Dite TA, Langendorf CG, Scott JW, Oakhill JS, Petersen J. Ling NXY, et al. Nat Metab. 2020 Jan;2(1):41-49. doi: 10.1038/s42255-019-0157-1. Epub 2020 Jan 20. Nat Metab. 2020. PMID: 31993556 Free PMC article.
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.
Pinkosky SL, Scott JW, Desjardins EM, Smith BK, Day EA, Ford RJ, Langendorf CG, Ling NXY, Nero TL, Loh K, Galic S, Hoque A, Smiles WJ, Ngoei KRW, Parker MW, Yan Y, Melcher K, Kemp BE, Oakhill JS, Steinberg GR. Pinkosky SL, et al. Among authors: ling nxy. Nat Metab. 2020 Sep;2(9):873-881. doi: 10.1038/s42255-020-0245-2. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719536 Free PMC article.
Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.
Neopane K, Kozlov N, Negoita F, Murray-Segal L, Brink R, Hoque A, Ovens AJ, Tjin G, McAloon LM, Yu D, Ling NXY, Sanders MJ, Oakhill JS, Scott JW, Steinberg GR, Loh K, Kemp BE, Sakamoto K, Galic S. Neopane K, et al. Among authors: ling nxy. Cell Rep. 2022 Dec 20;41(12):111862. doi: 10.1016/j.celrep.2022.111862. Cell Rep. 2022. PMID: 36543129 Free article.
30 results