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Page 1
Microbial scout hypothesis and microbial discovery.
Buerger S, Spoering A, Gavrish E, Leslin C, Ling L, Epstein SS. Buerger S, et al. Appl Environ Microbiol. 2012 May;78(9):3229-33. doi: 10.1128/AEM.07308-11. Epub 2012 Feb 24. Appl Environ Microbiol. 2012. PMID: 22367084 Free PMC article.
Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, Clardy J, Lewis K. Gavrish E, et al. Chem Biol. 2014 Apr 24;21(4):509-518. doi: 10.1016/j.chembiol.2014.01.014. Epub 2014 Mar 27. Chem Biol. 2014. PMID: 24684906 Free PMC article.
A new antibiotic kills pathogens without detectable resistance.
Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. Ling LL, et al. Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Nature. 2015. PMID: 25561178 Free PMC article.
Erratum: A new antibiotic kills pathogens without detectable resistance.
Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. Ling LL, et al. Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14303. Epub 2015 Feb 25. Nature. 2015. PMID: 25731174 No abstract available.
Reducing the Bottleneck in Discovery of Novel Antibiotics.
Jones MB, Nierman WC, Shan Y, Frank BC, Spoering A, Ling L, Peoples A, Zullo A, Lewis K, Nelson KE. Jones MB, et al. Microb Ecol. 2017 Apr;73(3):658-667. doi: 10.1007/s00248-016-0889-3. Epub 2016 Nov 28. Microb Ecol. 2017. PMID: 27896376
Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis.
Quigley J, Peoples A, Sarybaeva A, Hughes D, Ghiglieri M, Achorn C, Desrosiers A, Felix C, Liang L, Malveira S, Millett W, Nitti A, Tran B, Zullo A, Anklin C, Spoering A, Ling LL, Lewis K. Quigley J, et al. Among authors: ling ll. mBio. 2020 Aug 4;11(4):e01516-20. doi: 10.1128/mBio.01516-20. mBio. 2020. PMID: 32753498 Free PMC article.
Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin.
Wirtz DA, Ludwig KC, Arts M, Marx CE, Krannich S, Barac P, Kehraus S, Josten M, Henrichfreise B, Müller A, König GM, Peoples AJ, Nitti A, Spoering AL, Ling LL, Lewis K, Crüsemann M, Schneider T. Wirtz DA, et al. Among authors: ling ll. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13579-13586. doi: 10.1002/anie.202102224. Epub 2021 May 7. Angew Chem Int Ed Engl. 2021. PMID: 33768646 Free PMC article.
87 results