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Page 1
Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy.
Bhattacharjee A, Burr AHP, Overacre-Delgoffe AE, Tometich JT, Yang D, Huckestein BR, Linehan JL, Spencer SP, Hall JA, Harrison OJ, Morais da Fonseca D, Norton EB, Belkaid Y, Hand TW. Bhattacharjee A, et al. Among authors: linehan jl. Immunity. 2021 Aug 10;54(8):1745-1757.e7. doi: 10.1016/j.immuni.2021.07.005. Epub 2021 Aug 3. Immunity. 2021. PMID: 34348118 Free PMC article.
Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury.
Harrison OJ, Linehan JL, Shih HY, Bouladoux N, Han SJ, Smelkinson M, Sen SK, Byrd AL, Enamorado M, Yao C, Tamoutounour S, Van Laethem F, Hurabielle C, Collins N, Paun A, Salcedo R, O'Shea JJ, Belkaid Y. Harrison OJ, et al. Among authors: linehan jl. Science. 2019 Jan 4;363(6422):eaat6280. doi: 10.1126/science.aat6280. Epub 2018 Dec 6. Science. 2019. PMID: 30523076 Free PMC article.
Immunity to commensal skin fungi promotes psoriasiform skin inflammation.
Hurabielle C, Link VM, Bouladoux N, Han SJ, Merrill ED, Lightfoot YL, Seto N, Bleck CKE, Smelkinson M, Harrison OJ, Linehan JL, Tamoutounour S, Lionakis MS, Kaplan MJ, Nakajima S, Belkaid Y. Hurabielle C, et al. Among authors: linehan jl. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16465-16474. doi: 10.1073/pnas.2003022117. Epub 2020 Jun 29. Proc Natl Acad Sci U S A. 2020. PMID: 32601220 Free PMC article.
Keratinocyte-intrinsic MHCII expression controls microbiota-induced Th1 cell responses.
Tamoutounour S, Han SJ, Deckers J, Constantinides MG, Hurabielle C, Harrison OJ, Bouladoux N, Linehan JL, Link VM, Vujkovic-Cvijin I, Perez-Chaparro PJ, Rosshart SP, Rehermann B, Lazarevic V, Belkaid Y. Tamoutounour S, et al. Among authors: linehan jl. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23643-23652. doi: 10.1073/pnas.1912432116. Epub 2019 Oct 31. Proc Natl Acad Sci U S A. 2019. PMID: 31672911 Free PMC article.
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.
Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I, Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S, Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ, Belkaid Y. Linehan JL, et al. Cell. 2018 Feb 8;172(4):784-796.e18. doi: 10.1016/j.cell.2017.12.033. Epub 2018 Jan 18. Cell. 2018. PMID: 29358051 Free PMC article.
Commensal-dendritic-cell interaction specifies a unique protective skin immune signature.
Naik S, Bouladoux N, Linehan JL, Han SJ, Harrison OJ, Wilhelm C, Conlan S, Himmelfarb S, Byrd AL, Deming C, Quinones M, Brenchley JM, Kong HH, Tussiwand R, Murphy KM, Merad M, Segre JA, Belkaid Y. Naik S, et al. Among authors: linehan jl. Nature. 2015 Apr 2;520(7545):104-8. doi: 10.1038/nature14052. Epub 2015 Jan 5. Nature. 2015. PMID: 25539086 Free PMC article.
MAIT cells are imprinted by the microbiota in early life and promote tissue repair.
Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y. Constantinides MG, et al. Among authors: linehan jl. Science. 2019 Oct 25;366(6464):eaax6624. doi: 10.1126/science.aax6624. Science. 2019. PMID: 31649166 Free PMC article.
Focused specificity of intestinal TH17 cells towards commensal bacterial antigens.
Yang Y, Torchinsky MB, Gobert M, Xiong H, Xu M, Linehan JL, Alonzo F, Ng C, Chen A, Lin X, Sczesnak A, Liao JJ, Torres VJ, Jenkins MK, Lafaille JJ, Littman DR. Yang Y, et al. Among authors: linehan jl. Nature. 2014 Jun 5;510(7503):152-6. doi: 10.1038/nature13279. Epub 2014 Apr 13. Nature. 2014. PMID: 24739972 Free PMC article.
CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.
Kalekar LA, Schmiel SE, Nandiwada SL, Lam WY, Barsness LO, Zhang N, Stritesky GL, Malhotra D, Pauken KE, Linehan JL, O'Sullivan MG, Fife BT, Hogquist KA, Jenkins MK, Mueller DL. Kalekar LA, et al. Among authors: linehan jl. Nat Immunol. 2016 Mar;17(3):304-14. doi: 10.1038/ni.3331. Epub 2016 Feb 1. Nat Immunol. 2016. PMID: 26829766 Free PMC article.
Removing T-cell epitopes with computational protein design.
King C, Garza EN, Mazor R, Linehan JL, Pastan I, Pepper M, Baker D. King C, et al. Among authors: linehan jl. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8577-82. doi: 10.1073/pnas.1321126111. Epub 2014 May 19. Proc Natl Acad Sci U S A. 2014. PMID: 24843166 Free PMC article.
25 results