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New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy.
Uccello TP, Lesch ML, Kintzel SA, Gradzewicz LB, Lamrous L, Murphy SP, Fleming FJ, Mills BN, Murphy JD, Hughson A, Hannon G, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Keeley DC, Love TMT, Repasky EA, Lord EM, Linehan DC, Gerber SA. Uccello TP, et al. Among authors: linehan dc. Cell Death Dis. 2023 Jul 26;14(7):470. doi: 10.1038/s41419-023-05999-3. Cell Death Dis. 2023. PMID: 37495596 Free PMC article.
Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1.
Khazan N, Quarato ER, Singh NA, Snyder CWA, Moore T, Miller JP, Yasui M, Teramoto Y, Goto T, Reshi S, Hong J, Zhang N, Pandey D, Srivastava P, Morell A, Kawano H, Kawano Y, Conley T, Sahasrabudhe DM, Yano N, Miyamoto H, Aljitawi O, Liesveld J, Becker MW, Calvi LM, Zhovmer AS, Tabdanov ED, Dokholyan NV, Linehan DC, Hansen JN, Gerber SA, Sharon A, Khera MK, Jurutka PW, Rochel N, Kim KK, Rowswell-Turner RB, Singh RK, Moore RG. Khazan N, et al. Among authors: linehan dc. Cancers (Basel). 2023 Jun 30;15(13):3432. doi: 10.3390/cancers15133432. Cancers (Basel). 2023. PMID: 37444542 Free PMC article.
Smad4 restricts injury-provoked biliary proliferation and carcinogenesis.
Alexander WB, Wang W, Hill MA, O'Dell MR, Ruffolo LI, Guo B, Jackson KM, Ullman N, Friedland SC, McCall MN, Patel A, Figueroa-Guilliani N, Georger M, Belt BA, Whitney-Miller CL, Linehan DC, Murphy PJ, Hezel AF. Alexander WB, et al. Among authors: linehan dc. Dis Model Mech. 2024 Jun 1;17(6):dmm050358. doi: 10.1242/dmm.050358. Epub 2024 Feb 28. Dis Model Mech. 2024. PMID: 38415925 Free PMC article.
Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer.
Hughson AL, Hannon G, Salama NA, Vrooman TG, Stockwell CA, Mills BN, Garrett-Larsen J, Qiu H, Katerji R, Benoodt L, Johnston CJ, Murphy JD, Kruger E, Ye J, Gavras NW, Keeley DC, Qin SS, Lesch ML, Muhitch JB, Love TMT, Calvi LM, Lord EM, Luheshi N, Elyes J, Linehan DC, Gerber SA. Hughson AL, et al. Among authors: linehan dc. bioRxiv [Preprint]. 2023 Nov 2:2023.10.30.564833. doi: 10.1101/2023.10.30.564833. bioRxiv. 2023. PMID: 37961513 Free PMC article. Preprint.
Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity.
Williams HL, Dias Costa A, Zhang J, Raghavan S, Winter PS, Kapner KS, Ginebaugh SP, Väyrynen SA, Väyrynen JP, Yuan C, Navia AW, Wang J, Yang A, Bosse TL, Kalekar RL, Lowder KE, Lau MC, Elganainy D, Morales-Oyarvide V, Rubinson DA, Singh H, Perez K, Cleary JM, Clancy TE, Wang J, Mancias JD, Brais LK, Hill ER, Kozak MM, Linehan DC, Dunne RF, Chang DT, Koong AC, Hezel AF, Hahn WC, Shalek AK, Aguirre AJ, Nowak JA, Wolpin BM. Williams HL, et al. Among authors: linehan dc. Cancer Res. 2023 Feb 3;83(3):441-455. doi: 10.1158/0008-5472.CAN-22-3050. Cancer Res. 2023. PMID: 36459568 Free PMC article.
Radiation Therapy Exacerbates Tumor-Promoting Innervation and Nerve Signaling in Rectal Cancer.
Uccello TP, Lesch ML, Ullman NA, Kintzel SA, Gradzewicz LB, Velagaleti T, Fleming FJ, Mills BN, Murphy JD, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Johnston CJ, Love TMT, Repasky EA, Linehan DC, Lord EM, Gerber SA. Uccello TP, et al. Among authors: linehan dc. Int J Radiat Oncol Biol Phys. 2023 Mar 1;115(3):733-745. doi: 10.1016/j.ijrobp.2022.09.080. Epub 2022 Oct 4. Int J Radiat Oncol Biol Phys. 2023. PMID: 36202180 Free PMC article.
Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer.
Dias Costa A, Väyrynen SA, Chawla A, Zhang J, Väyrynen JP, Lau MC, Williams HL, Yuan C, Morales-Oyarvide V, Elganainy D, Singh H, Cleary JM, Perez K, Ng K, Freed-Pastor W, Mancias JD, Dougan SK, Wang J, Rubinson DA, Dunne RF, Kozak MM, Brais L, Reilly E, Clancy T, Linehan DC, Chang DT, Hezel AF, Koong AC, Aguirre AJ, Wolpin BM, Nowak JA. Dias Costa A, et al. Among authors: linehan dc. Clin Cancer Res. 2022 Dec 1;28(23):5167-5179. doi: 10.1158/1078-0432.CCR-22-1125. Clin Cancer Res. 2022. PMID: 36129461 Free PMC article.
Predictors of opioid-free discharge after laparoscopic cholecystectomy.
Melucci AD, Dave YA, Lynch OF, Hsu S, Erlick MR, Linehan DC, Moalem J; University of Rochester's Efforts to Decrease Unnecessary Controlled substances in Surgery (UReduces) Initiative. Melucci AD, et al. Among authors: linehan dc. Am J Surg. 2023 Jan;225(1):206-211. doi: 10.1016/j.amjsurg.2022.07.027. Epub 2022 Aug 3. Am J Surg. 2023. PMID: 35948514
Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer.
Ye J, Mills BN, Qin SS, Garrett-Larsen J, Murphy JD, Uccello TP, Han BJ, Vrooman TG, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA. Ye J, et al. Among authors: linehan dc. J Immunother Cancer. 2022 Jul;10(7):e004784. doi: 10.1136/jitc-2022-004784. J Immunother Cancer. 2022. PMID: 35851308 Free PMC article.
138 results