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Aliskiren displays long-lasting interactions with human renin.
Gossas T, Vrang L, Henderson I, Sedig S, Sahlberg C, Lindström E, Danielson UH. Gossas T, et al. Among authors: lindstrom e. Naunyn Schmiedebergs Arch Pharmacol. 2012 Feb;385(2):219-24. doi: 10.1007/s00210-011-0718-7. Epub 2011 Dec 23. Naunyn Schmiedebergs Arch Pharmacol. 2012. PMID: 22193701
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates.
Sund C, Belda O, Borkakoti N, Lindberg J, Derbyshire D, Vrang L, Hamelink E, Åhgren C, Woestenenk E, Wikström K, Eneroth A, Lindström E, Kalayanov G. Sund C, et al. Among authors: lindstrom e. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6721-7. doi: 10.1016/j.bmcl.2012.08.097. Epub 2012 Sep 5. Bioorg Med Chem Lett. 2012. PMID: 23010268
Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.
Hewitt E, Pitcher T, Rizoska B, Tunblad K, Henderson I, Sahlberg BL, Grabowska U, Classon B, Edenius C, Malcangio M, Lindström E. Hewitt E, et al. Among authors: lindstrom e. J Pharmacol Exp Ther. 2016 Sep;358(3):387-96. doi: 10.1124/jpet.116.232926. Epub 2016 Jun 22. J Pharmacol Exp Ther. 2016. PMID: 27335437
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW. Zhao P, et al. Among authors: lindstrom e. J Biol Chem. 2014 Sep 26;289(39):27215-27234. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12. J Biol Chem. 2014. PMID: 25118282 Free PMC article.
421 results