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Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders.
Steinebach C, Ng YLD, Sosič I, Lee CS, Chen S, Lindner S, Vu LP, Bricelj A, Haschemi R, Monschke M, Steinwarz E, Wagner KG, Bendas G, Luo J, Gütschow M, Krönke J. Steinebach C, et al. Among authors: lindner s. Chem Sci. 2020 Mar 4;11(13):3474-3486. doi: 10.1039/d0sc00167h. eCollection 2020 Apr 7. Chem Sci. 2020. PMID: 33133483 Free PMC article.
PROTAC-mediated crosstalk between E3 ligases.
Steinebach C , Kehm H , Lindner S , Vu LP , Köpff S , López Mármol Á , Weiler C , Wagner KG , Reichenzeller M , Krönke J , Gütschow M . Steinebach C , et al. Among authors: lindner s. Chem Commun (Camb). 2019 Feb 5;55(12):1821-1824. doi: 10.1039/c8cc09541h. Chem Commun (Camb). 2019. PMID: 30672516
Homo-PROTACs for the Chemical Knockdown of Cereblon.
Steinebach C, Lindner S, Udeshi ND, Mani DC, Kehm H, Köpff S, Carr SA, Gütschow M, Krönke J. Steinebach C, et al. Among authors: lindner s. ACS Chem Biol. 2018 Sep 21;13(9):2771-2782. doi: 10.1021/acschembio.8b00693. Epub 2018 Sep 5. ACS Chem Biol. 2018. PMID: 30118587
A MedChem toolbox for cereblon-directed PROTACs.
Steinebach C, Sosič I, Lindner S, Bricelj A, Kohl F, Ng YLD, Monschke M, Wagner KG, Krönke J, Gütschow M. Steinebach C, et al. Among authors: lindner s. Medchemcomm. 2019 May 28;10(6):1037-1041. doi: 10.1039/c9md00185a. eCollection 2019 Jun 1. Medchemcomm. 2019. PMID: 31304001 Free PMC article.
CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients.
Kaltenmeier C, Gawanbacht A, Beyer T, Lindner S, Trzaska T, van der Merwe JA, Härter G, Grüner B, Fabricius D, Lotfi R, Schwarz K, Schütz C, Hönig M, Schulz A, Kern P, Bommer M, Schrezenmeier H, Kirchhoff F, Jahrsdörfer B. Kaltenmeier C, et al. Among authors: lindner s. J Immunol. 2015 Apr 15;194(8):3768-77. doi: 10.4049/jimmunol.1402568. Epub 2015 Mar 16. J Immunol. 2015. PMID: 25780036
Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.
Lindner S, Dahlke K, Sontheimer K, Hagn M, Kaltenmeier C, Barth TF, Beyer T, Reister F, Fabricius D, Lotfi R, Lunov O, Nienhaus GU, Simmet T, Kreienberg R, Möller P, Schrezenmeier H, Jahrsdörfer B. Lindner S, et al. Cancer Res. 2013 Apr 15;73(8):2468-79. doi: 10.1158/0008-5472.CAN-12-3450. Epub 2013 Feb 5. Cancer Res. 2013. PMID: 23384943
476 results