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Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion.
Aliakbarinodehi N, Gallud A, Mapar M, Wesén E, Heydari S, Jing Y, Emilsson G, Liu K, Sabirsh A, Zhdanov VP, Lindfors L, Esbjörner EK, Höök F. Aliakbarinodehi N, et al. Among authors: lindfors l. ACS Nano. 2022 Dec 27;16(12):20163-20173. doi: 10.1021/acsnano.2c04829. Epub 2022 Dec 13. ACS Nano. 2022. PMID: 36511601 Free PMC article.
Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles.
Sebastiani F, Yanez Arteta M, Lerche M, Porcar L, Lang C, Bragg RA, Elmore CS, Krishnamurthy VR, Russell RA, Darwish T, Pichler H, Waldie S, Moulin M, Haertlein M, Forsyth VT, Lindfors L, Cárdenas M. Sebastiani F, et al. Among authors: lindfors l. ACS Nano. 2021 Apr 27;15(4):6709-6722. doi: 10.1021/acsnano.0c10064. Epub 2021 Mar 23. ACS Nano. 2021. PMID: 33754708 Free PMC article.
Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein.
Davies N, Hovdal D, Edmunds N, Nordberg P, Dahlén A, Dabkowska A, Arteta MY, Radulescu A, Kjellman T, Höijer A, Seeliger F, Holmedal E, Andihn E, Bergenhem N, Sandinge AS, Johansson C, Hultin L, Johansson M, Lindqvist J, Björsson L, Jing Y, Bartesaghi S, Lindfors L, Andersson S. Davies N, et al. Among authors: lindfors l. Mol Ther Nucleic Acids. 2021 Mar 13;24:369-384. doi: 10.1016/j.omtn.2021.03.008. eCollection 2021 Jun 4. Mol Ther Nucleic Acids. 2021. PMID: 33868782 Free PMC article.
Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale.
Paramasivam P, Franke C, Stöter M, Höijer A, Bartesaghi S, Sabirsh A, Lindfors L, Arteta MY, Dahlén A, Bak A, Andersson S, Kalaidzidis Y, Bickle M, Zerial M. Paramasivam P, et al. Among authors: lindfors l. J Cell Biol. 2022 Feb 7;221(2):e202110137. doi: 10.1083/jcb.202110137. Epub 2021 Dec 9. J Cell Biol. 2022. PMID: 34882187 Free PMC article.
Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions.
Nawaz M, Heydarkhan-Hagvall S, Tangruksa B, González-King Garibotti H, Jing Y, Maugeri M, Kohl F, Hultin L, Reyahi A, Camponeschi A, Kull B, Christoffersson J, Grimsholm O, Jennbacken K, Sundqvist M, Wiseman J, Bidar AW, Lindfors L, Synnergren J, Valadi H. Nawaz M, et al. Among authors: lindfors l. Adv Sci (Weinh). 2023 Apr;10(12):e2206187. doi: 10.1002/advs.202206187. Epub 2023 Feb 19. Adv Sci (Weinh). 2023. PMID: 36806740 Free PMC article.
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells.
Maugeri M, Nawaz M, Papadimitriou A, Angerfors A, Camponeschi A, Na M, Hölttä M, Skantze P, Johansson S, Sundqvist M, Lindquist J, Kjellman T, Mårtensson IL, Jin T, Sunnerhagen P, Östman S, Lindfors L, Valadi H. Maugeri M, et al. Among authors: lindfors l. Nat Commun. 2019 Sep 24;10(1):4333. doi: 10.1038/s41467-019-12275-6. Nat Commun. 2019. PMID: 31551417 Free PMC article.
50 results