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pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function.
Philipp J, Dabkowska A, Reiser A, Frank K, Krzysztoń R, Brummer C, Nickel B, Blanchet CE, Sudarsan A, Ibrahim M, Johansson S, Skantze P, Skantze U, Östman S, Johansson M, Henderson N, Elvevold K, Smedsrød B, Schwierz N, Lindfors L, Rädler JO. Philipp J, et al. Among authors: lindfors l. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2310491120. doi: 10.1073/pnas.2310491120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055742 Free PMC article.
Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions.
Nawaz M, Heydarkhan-Hagvall S, Tangruksa B, González-King Garibotti H, Jing Y, Maugeri M, Kohl F, Hultin L, Reyahi A, Camponeschi A, Kull B, Christoffersson J, Grimsholm O, Jennbacken K, Sundqvist M, Wiseman J, Bidar AW, Lindfors L, Synnergren J, Valadi H. Nawaz M, et al. Among authors: lindfors l. Adv Sci (Weinh). 2023 Apr;10(12):e2206187. doi: 10.1002/advs.202206187. Epub 2023 Feb 19. Adv Sci (Weinh). 2023. PMID: 36806740 Free PMC article.
Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion.
Aliakbarinodehi N, Gallud A, Mapar M, Wesén E, Heydari S, Jing Y, Emilsson G, Liu K, Sabirsh A, Zhdanov VP, Lindfors L, Esbjörner EK, Höök F. Aliakbarinodehi N, et al. Among authors: lindfors l. ACS Nano. 2022 Dec 27;16(12):20163-20173. doi: 10.1021/acsnano.2c04829. Epub 2022 Dec 13. ACS Nano. 2022. PMID: 36511601 Free PMC article.
Frequency-dependent signaling in cardiac myocytes.
Haftbaradaran Esfahani P, Westergren J, Lindfors L, Knöll R. Haftbaradaran Esfahani P, et al. Among authors: lindfors l. Front Physiol. 2022 Sep 2;13:926422. doi: 10.3389/fphys.2022.926422. eCollection 2022. Front Physiol. 2022. PMID: 36117711 Free PMC article.
50 results