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Page 1
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity.
O'Mara AE, Johnson JW, Linderman JD, Brychta RJ, McGehee S, Fletcher LA, Fink YA, Kapuria D, Cassimatis TM, Kelsey N, Cero C, Sater ZA, Piccinini F, Baskin AS, Leitner BP, Cai H, Millo CM, Dieckmann W, Walter M, Javitt NB, Rotman Y, Walter PJ, Ader M, Bergman RN, Herscovitch P, Chen KY, Cypess AM. O'Mara AE, et al. Among authors: linderman jd. J Clin Invest. 2020 May 1;130(5):2209-2219. doi: 10.1172/JCI131126. J Clin Invest. 2020. PMID: 31961826 Free PMC article. Clinical Trial.
Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature.
Chen KY, Brychta RJ, Linderman JD, Smith S, Courville A, Dieckmann W, Herscovitch P, Millo CM, Remaley A, Lee P, Celi FS. Chen KY, et al. Among authors: linderman jd. J Clin Endocrinol Metab. 2013 Jul;98(7):E1218-23. doi: 10.1210/jc.2012-4213. Epub 2013 Jun 18. J Clin Endocrinol Metab. 2013. PMID: 23780370 Free PMC article. Clinical Trial.
Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist.
Baskin AS, Linderman JD, Brychta RJ, McGehee S, Anflick-Chames E, Cero C, Johnson JW, O'Mara AE, Fletcher LA, Leitner BP, Duckworth CJ, Huang S, Cai H, Garraffo HM, Millo CM, Dieckmann W, Tolstikov V, Chen EY, Gao F, Narain NR, Kiebish MA, Walter PJ, Herscovitch P, Chen KY, Cypess AM. Baskin AS, et al. Among authors: linderman jd. Diabetes. 2018 Oct;67(10):2113-2125. doi: 10.2337/db18-0462. Epub 2018 Jul 6. Diabetes. 2018. PMID: 29980535 Free PMC article. Clinical Trial.
Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity.
Chen KY, Brychta RJ, Abdul Sater Z, Cassimatis TM, Cero C, Fletcher LA, Israni NS, Johnson JW, Lea HJ, Linderman JD, O'Mara AE, Zhu KY, Cypess AM. Chen KY, et al. Among authors: linderman jd. J Biol Chem. 2020 Feb 14;295(7):1926-1942. doi: 10.1074/jbc.REV119.007363. Epub 2019 Dec 30. J Biol Chem. 2020. PMID: 31914415 Free PMC article. Review.
Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans.
Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, Idelson C, Perron RM, Werner CD, Phan GQ, Kammula US, Kebebew E, Pacak K, Chen KY, Celi FS. Lee P, et al. Among authors: linderman jd. Cell Metab. 2014 Feb 4;19(2):302-9. doi: 10.1016/j.cmet.2013.12.017. Cell Metab. 2014. PMID: 24506871 Free PMC article. Clinical Trial.
Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults.
Celi FS, Brychta RJ, Linderman JD, Butler PW, Alberobello AT, Smith S, Courville AB, Lai EW, Costello R, Skarulis MC, Csako G, Remaley A, Pacak K, Chen KY. Celi FS, et al. Among authors: linderman jd. Eur J Endocrinol. 2010 Dec;163(6):863-72. doi: 10.1530/EJE-10-0627. Epub 2010 Sep 8. Eur J Endocrinol. 2010. PMID: 20826525 Free PMC article. Clinical Trial.
18 results