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Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy.
Linde MH, Fan AC, Köhnke T, Trotman-Grant AC, Gurev SF, Phan P, Zhao F, Haddock NL, Nuno KA, Gars EJ, Stafford M, Marshall PL, Dove CG, Linde IL, Landberg N, Miller LP, Majzner RG, Zhang TY, Majeti R. Linde MH, et al. Among authors: linde il. Cancer Discov. 2023 May 4;13(5):1164-1185. doi: 10.1158/2159-8290.CD-21-0502. Cancer Discov. 2023. PMID: 36856575
Neutrophil-activating therapy for the treatment of cancer.
Linde IL, Prestwood TR, Qiu J, Pilarowski G, Linde MH, Zhang X, Shen L, Reticker-Flynn NE, Chiu DK, Sheu LY, Van Deursen S, Tolentino LL, Song WC, Engleman EG. Linde IL, et al. Cancer Cell. 2023 Feb 13;41(2):356-372.e10. doi: 10.1016/j.ccell.2023.01.002. Epub 2023 Jan 26. Cancer Cell. 2023. PMID: 36706760 Free PMC article.
Immune evasion of dormant disseminated tumor cells is due to their scarcity and can be overcome by T cell immunotherapies.
Goddard ET, Linde MH, Srivastava S, Klug G, Shabaneh TB, Iannone S, Grzelak CA, Marsh S, Riggio AI, Shor RE, Linde IL, Guerrero M, Veatch JR, Snyder AG, Welm AL, Riddell SR, Ghajar CM. Goddard ET, et al. Among authors: linde il. Cancer Cell. 2024 Jan 8;42(1):119-134.e12. doi: 10.1016/j.ccell.2023.12.011. Cancer Cell. 2024. PMID: 38194912
Melanoma-Secreted Lysosomes Trigger Monocyte-Derived Dendritic Cell Apoptosis and Limit Cancer Immunotherapy.
Santana-Magal N, Farhat-Younis L, Gutwillig A, Gleiberman A, Rasoulouniriana D, Tal L, Netanely D, Shamir R, Blau R, Feinmesser M, Zlotnik O, Gutman H, Linde IL, Reticker-Flynn NE, Rider P, Carmi Y. Santana-Magal N, et al. Among authors: linde il. Cancer Res. 2020 May 15;80(10):1942-1956. doi: 10.1158/0008-5472.CAN-19-2944. Epub 2020 Mar 3. Cancer Res. 2020. PMID: 32127354
Lymph node colonization induces tumor-immune tolerance to promote distant metastasis.
Reticker-Flynn NE, Zhang W, Belk JA, Basto PA, Escalante NK, Pilarowski GOW, Bejnood A, Martins MM, Kenkel JA, Linde IL, Bagchi S, Yuan R, Chang S, Spitzer MH, Carmi Y, Cheng J, Tolentino LL, Choi O, Wu N, Kong CS, Gentles AJ, Sunwoo JB, Satpathy AT, Plevritis SK, Engleman EG. Reticker-Flynn NE, et al. Among authors: linde il. Cell. 2022 May 26;185(11):1924-1942.e23. doi: 10.1016/j.cell.2022.04.019. Epub 2022 May 6. Cell. 2022. PMID: 35525247 Free PMC article.
Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity.
Carmi Y, Prestwood TR, Spitzer MH, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG. Carmi Y, et al. Among authors: linde il. JCI Insight. 2016 Nov 3;1(18):e89020. doi: 10.1172/jci.insight.89020. JCI Insight. 2016. PMID: 27812544 Free PMC article.
A versatile system to record cell-cell interactions.
Tang R, Murray CW, Linde IL, Kramer NJ, Lyu Z, Tsai MK, Chen LC, Cai H, Gitler AD, Engleman E, Lee W, Winslow MM. Tang R, et al. Among authors: linde il. Elife. 2020 Oct 7;9:e61080. doi: 10.7554/eLife.61080. Elife. 2020. PMID: 33025906 Free PMC article.