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The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice.
Chen CM, Chen WL, Hung CT, Lin TH, Chao CY, Lin CH, Wu YR, Chang KH, Yao CF, Lee-Chen GJ, Su MT, Hsieh-Li HM. Chen CM, et al. Among authors: lin ch, lin th. Neurotoxicology. 2018 Jul;67:259-269. doi: 10.1016/j.neuro.2018.06.009. Epub 2018 Jun 21. Neurotoxicology. 2018. PMID: 29936316
Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3.
Chen CM, Weng YT, Chen WL, Lin TH, Chao CY, Lin CH, Chen IC, Lee LC, Lin HY, Wu YR, Chen YC, Chang KH, Tang HY, Cheng ML, Lee-Chen GJ, Lin JY. Chen CM, et al. Among authors: lin ch, lin hy, lin th, lin jy. Free Radic Biol Med. 2014 Jun;71:339-350. doi: 10.1016/j.freeradbiomed.2014.03.023. Epub 2014 Mar 25. Free Radic Biol Med. 2014. PMID: 24675225
The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity.
Chang KH, Chiu YJ, Chen SL, Huang CH, Lin CH, Lin TH, Lee CM, Ramesh C, Wu CH, Huang CC, Fung HC, Chen YC, Lin JY, Yao CF, Huang HJ, Lee-Chen GJ, Lee MC, Hsieh-Li HM. Chang KH, et al. Among authors: lin ch, lin th, lin jy. Neuropharmacology. 2016 Feb;101:309-19. doi: 10.1016/j.neuropharm.2015.09.005. Epub 2015 Sep 8. Neuropharmacology. 2016. PMID: 26362358
Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression.
Chen CM, Chen IC, Chen YL, Lin TH, Chen WL, Chao CY, Wu YR, Lu YT, Lee CY, Chien HC, Chen TS, Lee-Chen GJ, Lee CM. Chen CM, et al. Among authors: lin th. Phytomedicine. 2016 Nov 15;23(12):1422-1433. doi: 10.1016/j.phymed.2016.08.004. Epub 2016 Aug 20. Phytomedicine. 2016. PMID: 27765362
The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease.
Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM. Chang KH, et al. Among authors: lin ch, lin hy, lin th, lin jy. Drug Des Devel Ther. 2016 Feb 29;10:885-96. doi: 10.2147/DDDT.S96454. eCollection 2016. Drug Des Devel Ther. 2016. PMID: 27013866 Free PMC article.
1,571 results