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The nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate/D-NO), increases survival by attenuating hyperoxia-compromised innate immunity in bacterial clearance in a mouse model of ventilator-associated pneumonia.
Gore A, Gauthier AG, Lin M, Patel V, Thomas DD, Ashby CR Jr, Mantell LL. Gore A, et al. Among authors: lin m. Biochem Pharmacol. 2020 Jun;176:113817. doi: 10.1016/j.bcp.2020.113817. Epub 2020 Jan 20. Biochem Pharmacol. 2020. PMID: 31972169 Free PMC article.
The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.
Sitapara RA, Gauthier AG, Valdés-Ferrer SI, Lin M, Patel V, Wang M, Martino AT, Perron JC, Ashby CR Jr, Tracey KJ, Pavlov VA, Mantell LL. Sitapara RA, et al. Among authors: lin m. Mol Med. 2020 Jun 29;26(1):63. doi: 10.1186/s10020-020-00177-z. Mol Med. 2020. PMID: 32600307 Free PMC article.
The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages.
Gauthier AG, Wu J, Lin M, Sitapara R, Kulkarni A, Thakur GA, Schmidt EE, Perron JC, Ashby CR Jr, Mantell LL. Gauthier AG, et al. Among authors: lin m. Antioxidants (Basel). 2021 Jan 19;10(1):135. doi: 10.3390/antiox10010135. Antioxidants (Basel). 2021. PMID: 33477969 Free PMC article.
Correction to: 2‑O, 3‑O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1‑compromised macrophage function.
Wang M, Gauthier AG, Kennedy TP, Wang H, Velagapudi UK, Talele TT, Lin M, Wu J, Daley L, Yang X, Patel V, Mun SS, Ashby CR Jr, Mantell LL. Wang M, et al. Among authors: lin m. Mol Med. 2021 Sep 3;27(1):98. doi: 10.1186/s10020-021-00354-8. Mol Med. 2021. PMID: 34479472 Free PMC article. No abstract available.
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