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Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.
An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P, Zhang P, Yu X, Sun JP. An W, et al. Among authors: lin h. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2117004119. doi: 10.1073/pnas.2117004119. Epub 2022 Apr 8. Proc Natl Acad Sci U S A. 2022. PMID: 35394864 Free PMC article.
Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.
Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X. Xiao P, et al. Among authors: lin h. Nature. 2022 Apr;604(7907):771-778. doi: 10.1038/s41586-022-04590-8. Epub 2022 Apr 13. Nature. 2022. PMID: 35418677
Structures of the ADGRG2-Gs complex in apo and ligand-bound forms.
Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X. Lin H, et al. Among authors: lin hc. Nat Chem Biol. 2022 Nov;18(11):1196-1203. doi: 10.1038/s41589-022-01084-6. Epub 2022 Aug 18. Nat Chem Biol. 2022. PMID: 35982227
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D, Yu X, Sun JP. Zhang DL, et al. Among authors: lin a, lin h. Elife. 2018 Feb 2;7:e33432. doi: 10.7554/eLife.33432. Elife. 2018. PMID: 29393851 Free PMC article.
Deletion of pancreatic β-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia.
Ahmed Abdalhamid Osman M, Sun YJ, Li RJ, Lin H, Zeng DM, Chen XY, He D, Feng HW, Yang Z, Wang J, Wu C, Cui M, Sun JP, Huo Y, Yu X. Ahmed Abdalhamid Osman M, et al. Among authors: lin h. J Cell Mol Med. 2019 Jul;23(7):4653-4665. doi: 10.1111/jcmm.14216. Epub 2019 May 1. J Cell Mol Med. 2019. PMID: 31044530 Free PMC article.
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