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Thiazolidinedione-Based Structure Modification of Celastrol Provides Thiazolidinedione-Conjugated Derivatives as Potent Agents against Non-Small-Cell Lung Cancer Cells through a Mitochondria-Mediated Apoptotic Pathway.
Fu X, Mao Q, Zhang B, Lv J, Ping K, Zhang P, Lin F, Zhao J, Feng Y, Yang J, Wang H, Zhang L, Mou Y, Wang S. Fu X, et al. Among authors: lin f. J Nat Prod. 2022 Apr 22;85(4):1147-1156. doi: 10.1021/acs.jnatprod.2c00104. Epub 2022 Mar 7. J Nat Prod. 2022. PMID: 35255689 Review.
Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y1 and P2Y12 as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than Ticagrelor.
Lei Y, Zhang B, Liu D, Zhao J, Dai X, Gao J, Mao Q, Feng Y, Zhao J, Lin F, Duan Y, Zhang Y, Bao Z, Yang Y, Mou Y, Wang S. Lei Y, et al. Among authors: lin f. J Med Chem. 2020 Dec 24;63(24):15752-15772. doi: 10.1021/acs.jmedchem.0c01524. Epub 2020 Dec 12. J Med Chem. 2020. PMID: 33307675
Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
Zhang B, Duan Y, Yang Y, Mao Q, Lin F, Gao J, Dai X, Zhang P, Li Q, Li J, Dai R, Wang S. Zhang B, et al. Among authors: lin f. Eur J Med Chem. 2022 Jan 5;227:113928. doi: 10.1016/j.ejmech.2021.113928. Epub 2021 Oct 19. Eur J Med Chem. 2022. PMID: 34688012
Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors.
Zhao J, Mao Q, Lin F, Zhang B, Sun M, Zhang T, Wang S. Zhao J, et al. Among authors: lin f. Eur J Med Chem. 2022 Feb 5;229:114086. doi: 10.1016/j.ejmech.2021.114086. Epub 2021 Dec 29. Eur J Med Chem. 2022. PMID: 34992040
Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA-PABA-MAC and 5-ASA-PABA-Diamine for the Treatment of Ulcerative Colitis.
Zhao J, Zhang B, Mao Q, Ping K, Zhang P, Lin F, Liu D, Feng Y, Sun M, Zhang Y, Li QH, Zhang T, Mou Y, Wang S. Zhao J, et al. Among authors: lin f. J Med Chem. 2022 Mar 24;65(6):4926-4948. doi: 10.1021/acs.jmedchem.1c02166. Epub 2022 Mar 11. J Med Chem. 2022. PMID: 35275619
9,402 results