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Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling.
Lopes JPB, Silva L, Ceschi MA, Lüdtke DS, Zimmer AR, Ruaro TC, Dantas RF, de Salles CMC, Silva-Jr FP, Senger MR, Barbosa G, Lima LM, Guedes IA, Dardenne LE. Lopes JPB, et al. Among authors: lima lm. Medchemcomm. 2019 Nov 8;10(12):2089-2101. doi: 10.1039/c9md00358d. eCollection 2019 Dec 1. Medchemcomm. 2019. PMID: 32904099 Free PMC article.
Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies.
Nunes IKDC, de Souza ET, Martins IRR, Barbosa G, Moraes Junior MO, Medeiros MM, Silva SWD, Balliano TL, da Silva BA, Silva PMR, Carvalho VF, Martins MA, Lima LM. Nunes IKDC, et al. Among authors: lima lm. Eur J Med Chem. 2020 Oct 15;204:112492. doi: 10.1016/j.ejmech.2020.112492. Epub 2020 Jul 18. Eur J Med Chem. 2020. PMID: 32717478
Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation.
Cristancho Ortiz CJ, de Freitas Silva M, Pruccoli L, Fonseca Nadur N, de Azevedo LL, Kümmerle AE, Guedes IA, Dardenne LE, Leomil Coelho LF, Guimarães MJ, da Silva FMR, Castro N, Gontijo VS, Rojas VCT, de Oliveira MK, Vilela FC, Giusti-Paiva A, Barbosa G, Lima LM, Pinheiro GB, Veras LG, Mortari MR, Tarozzi A, Viegas C Jr. Cristancho Ortiz CJ, et al. Among authors: lima lm. RSC Med Chem. 2022 Mar 17;13(5):568-584. doi: 10.1039/d1md00374g. eCollection 2022 May 25. RSC Med Chem. 2022. PMID: 35694691 Free PMC article.
Design, Synthesis and Phenotypic Profiling of Simplified Gedatolisib Analogues.
Costa CMX, Aparecida-Silva C, Gamba LER, de Melo TN, Barbosa G, Moraes Junior MO, de Oliveira VRT, de Amorim CS, Moraes JA, Barreiro EJ, Lima LM. Costa CMX, et al. Among authors: lima lm. Pharmaceuticals (Basel). 2023 Jan 30;16(2):209. doi: 10.3390/ph16020209. Pharmaceuticals (Basel). 2023. PMID: 37259357 Free PMC article.
410 results