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A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer's disease.
Bellozi PMQ, Gomes GF, da Silva MCM, Lima IVA, Batista CRÁ, Carneiro Junior WO, Dória JG, Vieira ÉLM, Vieira RP, de Freitas RP, Ferreira CN, Candelario-Jalil E, Wyss-Coray T, Ribeiro FM, de Oliveira ACP. Bellozi PMQ, et al. Among authors: lima iva. Neuropharmacology. 2019 Dec 1;160:107785. doi: 10.1016/j.neuropharm.2019.107785. Epub 2019 Sep 18. Neuropharmacology. 2019. PMID: 31541651
Cannabidiol anticonvulsant effect is mediated by the PI3Kγ pathway.
Lima IVA, Bellozi PMQ, Batista EM, Vilela LR, Brandão IL, Ribeiro FM, Moraes MFD, Moreira FA, de Oliveira ACP. Lima IVA, et al. Neuropharmacology. 2020 Oct 1;176:108156. doi: 10.1016/j.neuropharm.2020.108156. Epub 2020 Jun 20. Neuropharmacology. 2020. PMID: 32574650
PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine.
Lima IV, Campos AC, Miranda AS, Vieira ÉL, Amaral-Martins F, Vago JP, Santos RP, Sousa LP, Vieira LB, Teixeira MM, Fiebich BL, Moraes MF, Teixeira AL, de Oliveira AC. Lima IV, et al. Exp Neurol. 2015 May;267:123-34. doi: 10.1016/j.expneurol.2015.02.021. Epub 2015 Mar 5. Exp Neurol. 2015. PMID: 25749189
A new lipophilic amino alcohol, chemically similar to compound FTY720, attenuates the pathogenesis of experimental autoimmune encephalomyelitis by PI3K/Akt pathway inhibition.
da Silva LC, Lima IVA, da Silva MCM, Corrêa TA, de Souza VP, de Almeida MV, de Oliveira ACP, Ferreira AP. da Silva LC, et al. Among authors: lima iva. Int Immunopharmacol. 2020 Nov;88:106919. doi: 10.1016/j.intimp.2020.106919. Epub 2020 Aug 29. Int Immunopharmacol. 2020. PMID: 32871475
14 results