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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J; Collaborative Association Study of Psoriasis (CASP); Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetics Extension; Wellcome Trust Case Control Consortium 2; Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC. Tsoi LC, et al. Among authors: lim hw. Nat Genet. 2012 Dec;44(12):1341-8. doi: 10.1038/ng.2467. Epub 2012 Nov 11. Nat Genet. 2012. PMID: 23143594 Free PMC article.
Variations in the HCR (Pg8) gene are unlikely to be causal for familial psoriasis.
Chia NV, Stuart P, Nair RP, Henseler T, Jenisch S, Lim HW, Christophers E, Voorhees JJ, Elder JT. Chia NV, et al. Among authors: lim hw. J Invest Dermatol. 2001 May;116(5):823-4. doi: 10.1046/j.1523-1747.2001.01245-2.x. J Invest Dermatol. 2001. PMID: 11348479 Free article. No abstract available.
Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage.
Stuart P, Nair RP, Abecasis GR, Nistor I, Hiremagalore R, Chia NV, Qin ZS, Thompson RA, Jenisch S, Weichenthal M, Janiga J, Lim HW, Christophers E, Voorhees JJ, Elder JT. Stuart P, et al. Among authors: lim hw. J Med Genet. 2006 Jan;43(1):12-7. doi: 10.1136/jmg.2005.032193. Epub 2005 May 27. J Med Genet. 2006. PMID: 15923274 Free PMC article.
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.
Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NVC, Jenisch S, Weichenthal M, Abecasis GR, Lim HW, Christophers E, Voorhees JJ, Elder JT. Nair RP, et al. Among authors: lim hw. Am J Hum Genet. 2006 May;78(5):827-851. doi: 10.1086/503821. Epub 2006 Mar 31. Am J Hum Genet. 2006. PMID: 16642438 Free PMC article.
Polymorphisms of the IL12B and IL23R genes are associated with psoriasis.
Nair RP, Ruether A, Stuart PE, Jenisch S, Tejasvi T, Hiremagalore R, Schreiber S, Kabelitz D, Lim HW, Voorhees JJ, Christophers E, Elder JT, Weichenthal M. Nair RP, et al. Among authors: lim hw. J Invest Dermatol. 2008 Jul;128(7):1653-61. doi: 10.1038/sj.jid.5701255. Epub 2008 Jan 24. J Invest Dermatol. 2008. PMID: 18219280 Free PMC article.
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR; Collaborative Association Study of Psoriasis. Nair RP, et al. Nat Genet. 2009 Feb;41(2):199-204. doi: 10.1038/ng.311. Epub 2009 Jan 25. Nat Genet. 2009. PMID: 19169254 Free PMC article.
788 results