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FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter JC, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A. Wieder N, et al. Among authors: lim d. Cell Metab. 2023 May 2;35(5):887-905.e11. doi: 10.1016/j.cmet.2023.03.018. Epub 2023 Apr 18. Cell Metab. 2023. PMID: 37075753 Free PMC article.
CRISPR-based therapeutics: current challenges and future applications.
Modell AE, Lim D, Nguyen TM, Sreekanth V, Choudhary A. Modell AE, et al. Among authors: lim d. Trends Pharmacol Sci. 2022 Feb;43(2):151-161. doi: 10.1016/j.tips.2021.10.012. Epub 2021 Dec 21. Trends Pharmacol Sci. 2022. PMID: 34952739 Free PMC article. Review.
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules.
Lim D, Zhou Q, Cox KJ, Law BK, Lee M, Kokkonda P, Sreekanth V, Pergu R, Chaudhary SK, Gangopadhyay SA, Maji B, Lai S, Amako Y, Thompson DB, Subramanian HKK, Mesleh MF, Dančík V, Clemons PA, Wagner BK, Woo CM, Church GM, Choudhary A. Lim D, et al. Nat Cell Biol. 2022 Dec;24(12):1766-1775. doi: 10.1038/s41556-022-01005-8. Epub 2022 Nov 17. Nat Cell Biol. 2022. PMID: 36396978 Free PMC article.
A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.
Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, Clemons PA, Wagner BK, Choudhary A. Maji B, et al. Among authors: lim d. Cell. 2019 May 2;177(4):1067-1079.e19. doi: 10.1016/j.cell.2019.04.009. Cell. 2019. PMID: 31051099 Free PMC article.
Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes.
Sreekanth V, Zhou Q, Kokkonda P, Bermudez-Cabrera HC, Lim D, Law BK, Holmes BR, Chaudhary SK, Pergu R, Leger BS, Walker JA, Gifford DK, Sherwood RI, Choudhary A. Sreekanth V, et al. Among authors: lim d. ACS Cent Sci. 2020 Dec 23;6(12):2228-2237. doi: 10.1021/acscentsci.0c00129. Epub 2020 Nov 18. ACS Cent Sci. 2020. PMID: 33376784 Free PMC article.
Rational Design of Silicon-Based Zinc Ionophores.
Yamada K, Deb A, Shoba VM, Lim D, Maji B, Modell AE, Choudhary A. Yamada K, et al. Among authors: lim d. Angew Chem Int Ed Engl. 2022 Jun 7;61(23):e202201698. doi: 10.1002/anie.202201698. Epub 2022 Apr 6. Angew Chem Int Ed Engl. 2022. PMID: 35385189 Free PMC article.
Precision Control of CRISPR-Cas9 Using Small Molecules and Light.
Gangopadhyay SA, Cox KJ, Manna D, Lim D, Maji B, Zhou Q, Choudhary A. Gangopadhyay SA, et al. Among authors: lim d. Biochemistry. 2019 Jan 29;58(4):234-244. doi: 10.1021/acs.biochem.8b01202. Epub 2019 Jan 22. Biochemistry. 2019. PMID: 30640437 Free PMC article. Review.
4,592 results