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Cyto-Mine: An Integrated, Picodroplet System for High-Throughput Single-Cell Analysis, Sorting, Dispensing, and Monoclonality Assurance.
Josephides D, Davoli S, Whitley W, Ruis R, Salter R, Gokkaya S, Vallet M, Matthews D, Benazzi G, Shvets E, Gesellchen F, Geere D, Liu X, Li X, Mackworth B, Young W, Owen Z, Smith C, Starkie D, White J, Sweeney B, Hinchliffe M, Tickle S, Lightwood DJ, Rehak M, Craig FF, Holmes D. Josephides D, et al. Among authors: lightwood dj. SLAS Technol. 2020 Apr;25(2):177-189. doi: 10.1177/2472630319892571. Epub 2020 Jan 15. SLAS Technol. 2020. PMID: 31941402
The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method.
Clargo AM, Hudson AR, Ndlovu W, Wootton RJ, Cremin LA, O'Dowd VL, Nowosad CR, Starkie DO, Shaw SP, Compson JE, White DP, MacKenzie B, Snowden JR, Newnham LE, Wright M, Stephens PE, Griffiths MR, Lawson AD, Lightwood DJ. Clargo AM, et al. Among authors: lightwood dj. MAbs. 2014 Jan-Feb;6(1):143-59. doi: 10.4161/mabs.27044. MAbs. 2014. PMID: 24423622 Free PMC article.
Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells.
Neumeier D, Yermanos A, Agrafiotis A, Csepregi L, Chowdhury T, Ehling RA, Kuhn R, Cotet TS, Brisset-Di Roberto R, Di Tacchio M, Antonialli R, Starkie D, Lightwood DJ, Oxenius A, Reddy ST. Neumeier D, et al. Among authors: lightwood dj. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2113766119. doi: 10.1073/pnas.2113766119. Epub 2022 Apr 29. Proc Natl Acad Sci U S A. 2022. PMID: 35486691 Free PMC article.
Rapid isolation of antigen-specific B-cells using droplet microfluidics.
Ding R, Hung KC, Mitra A, Ung LW, Lightwood D, Tu R, Starkie D, Cai L, Mazutis L, Chong S, Weitz DA, Heyman JA. Ding R, et al. RSC Adv. 2020 Jul 20;10(45):27006-27013. doi: 10.1039/d0ra04328a. eCollection 2020 Jul 15. RSC Adv. 2020. PMID: 35515810 Free PMC article.
Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen specificity.
Agrafiotis A, Neumeier D, Hong KL, Chowdhury T, Ehling R, Kuhn R, Sandu I, Kreiner V, Cotet TS, Shlesinger D, Laslo D, Anzböck S, Starkie D, Lightwood DJ, Oxenius A, Reddy ST, Yermanos A. Agrafiotis A, et al. Among authors: lightwood dj. iScience. 2023 Jan 25;26(3):106055. doi: 10.1016/j.isci.2023.106055. eCollection 2023 Mar 17. iScience. 2023. PMID: 36852274 Free PMC article.
Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau.
Courade JP, Angers R, Mairet-Coello G, Pacico N, Tyson K, Lightwood D, Munro R, McMillan D, Griffin R, Baker T, Starkie D, Nan R, Westwood M, Mushikiwabo ML, Jung S, Odede G, Sweeney B, Popplewell A, Burgess G, Downey P, Citron M. Courade JP, et al. Acta Neuropathol. 2018 Nov;136(5):729-745. doi: 10.1007/s00401-018-1911-2. Epub 2018 Sep 20. Acta Neuropathol. 2018. PMID: 30238240 Free PMC article.
In vitro and in vivo characterisation of anti-murine IL-13 antibodies recognising distinct functional epitopes.
Berry LM, Adams R, Airey M, Bracher MG, Bourne T, Carrington B, Cross AS, Davies GC, Finney HM, Foulkes R, Gozzard N, Griffin RA, Hailu H, Lamour SD, Lawson AD, Lightwood DJ, McKnight AJ, O'Dowd VL, Oxbrow AK, Popplewell AG, Shaw S, Stephens PE, Sweeney B, Tomlinson KL, Uhe C, Palframan RT. Berry LM, et al. Among authors: lightwood dj. Int Immunopharmacol. 2009 Feb;9(2):201-6. doi: 10.1016/j.intimp.2008.11.001. Epub 2008 Nov 27. Int Immunopharmacol. 2009. PMID: 19041426
Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration.
Smith B, Kiessling A, Lledo-Garcia R, Dixon KL, Christodoulou L, Catley MC, Atherfold P, D'Hooghe LE, Finney H, Greenslade K, Hailu H, Kevorkian L, Lightwood D, Meier C, Munro R, Qureshi O, Sarkar K, Shaw SP, Tewari R, Turner A, Tyson K, West S, Shaw S, Brennan FR. Smith B, et al. MAbs. 2018 Oct;10(7):1111-1130. doi: 10.1080/19420862.2018.1505464. Epub 2018 Sep 12. MAbs. 2018. PMID: 30130439 Free PMC article.
27 results