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Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.
Nat Biotechnol. 2022 Dec;40(12):1834-1844. doi: 10.1038/s41587-022-01386-z. Epub 2022 Jul 25.
Nat Biotechnol. 2022.
PMID: 35879364
Free PMC article.
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P.
Torres SE, et al. Among authors: liem cr.
Elife. 2019 May 31;8:e46595. doi: 10.7554/eLife.46595.
Elife. 2019.
PMID: 31149896
Free PMC article.
Item in Clipboard
Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.
Jost M, Santos DA, Saunders RA, Horlbeck MA, Hawkins JS, Scaria SM, Norman TM, Hussmann JA, Liem CR, Gross CA, Weissman JS.
Jost M, et al. Among authors: liem cr.
Nat Biotechnol. 2020 Mar;38(3):355-364. doi: 10.1038/s41587-019-0387-5. Epub 2020 Jan 13.
Nat Biotechnol. 2020.
PMID: 31932729
Free PMC article.
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High-content imaging-based pooled CRISPR screens in mammalian cells.
Yan X, Stuurman N, Ribeiro SA, Tanenbaum ME, Horlbeck MA, Liem CR, Jost M, Weissman JS, Vale RD.
Yan X, et al. Among authors: liem cr.
J Cell Biol. 2021 Feb 1;220(2):e202008158. doi: 10.1083/jcb.202008158.
J Cell Biol. 2021.
PMID: 33465779
Free PMC article.
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Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.
Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M.
Replogle JM, et al. Among authors: liem cr.
Elife. 2022 Dec 28;11:e81856. doi: 10.7554/eLife.81856.
Elife. 2022.
PMID: 36576240
Free PMC article.
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Endoplasmic reticulum tubules limit the size of misfolded protein condensates.
Parashar S, Chidambaram R, Chen S, Liem CR, Griffis E, Lambert GG, Shaner NC, Wortham M, Hay JC, Ferro-Novick S.
Parashar S, et al. Among authors: liem cr.
Elife. 2021 Sep 1;10:e71642. doi: 10.7554/eLife.71642.
Elife. 2021.
PMID: 34467852
Free PMC article.
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