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Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity.
Güner G, Aßfalg M, Zhao K, Dreyer T, Lahiri S, Lo Y, Slivinschi BI, Imhof A, Jocher G, Strohm L, Behrends C, Langosch D, Bronger H, Nimsky C, Bartsch JW, Riddell SR, Steiner H, Lichtenthaler SF. Güner G, et al. Among authors: lichtenthaler sf. EMBO Mol Med. 2022 Oct 10;14(10):e16084. doi: 10.15252/emmm.202216084. Epub 2022 Sep 7. EMBO Mol Med. 2022. PMID: 36069059 Free PMC article.
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.
Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, Lichtenthaler SF. Mitterreiter S, et al. Among authors: lichtenthaler sf. J Neurosci. 2010 Jun 30;30(26):8974-83. doi: 10.1523/JNEUROSCI.1199-10.2010. J Neurosci. 2010. PMID: 20592218 Free PMC article.
ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch JW. Moss ML, et al. Among authors: lichtenthaler sf. J Biol Chem. 2011 Nov 25;286(47):40443-51. doi: 10.1074/jbc.M111.280495. Epub 2011 Sep 28. J Biol Chem. 2011. PMID: 21956108 Free PMC article.
Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).
Voss M, Fukumori A, Kuhn PH, Künzel U, Klier B, Grammer G, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Haass C, Fluhrer R. Voss M, et al. Among authors: lichtenthaler sf. J Biol Chem. 2012 Dec 21;287(52):43401-9. doi: 10.1074/jbc.M112.371369. Epub 2012 Nov 6. J Biol Chem. 2012. PMID: 23132852 Free PMC article.
187 results