Liang XH - Search Results

1

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.

Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST. Shen W, et al. Among authors: liang xh. Nat Biotechnol. 2019 Jun;37(6):640-650. doi: 10.1038/s41587-019-0106-2. Epub 2019 Apr 29. Nat Biotechnol. 2019. PMID: 31036929

2

Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures.

Shen W, Liang XH, Crooke ST. Shen W, et al. Among authors: liang xh. Nucleic Acids Res. 2014 Jul;42(13):8648-62. doi: 10.1093/nar/gku579. Epub 2014 Jul 10. Nucleic Acids Res. 2014. PMID: 25013176 Free PMC article.

3

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity.

Liang XH, Shen W, Sun H, Kinberger GA, Prakash TP, Nichols JG, Crooke ST. Liang XH, et al. Nucleic Acids Res. 2016 May 5;44(8):3892-907. doi: 10.1093/nar/gkw144. Epub 2016 Mar 3. Nucleic Acids Res. 2016. PMID: 26945041 Free PMC article.

4

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.

Liang XH, Shen W, Sun H, Migawa MT, Vickers TA, Crooke ST. Liang XH, et al. Nat Biotechnol. 2016 Aug;34(8):875-80. doi: 10.1038/nbt.3589. Epub 2016 Jul 11. Nat Biotechnol. 2016. PMID: 27398791

5

Cellular uptake and trafficking of antisense oligonucleotides.

Crooke ST, Wang S, Vickers TA, Shen W, Liang XH. Crooke ST, et al. Among authors: liang xh. Nat Biotechnol. 2017 Mar;35(3):230-237. doi: 10.1038/nbt.3779. Epub 2017 Feb 27. Nat Biotechnol. 2017. PMID: 28244996 Review.

6

Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.

Liang XH, Nichols JG, De Hoyos CL, Sun H, Zhang L, Crooke ST. Liang XH, et al. Nucleic Acids Res. 2021 Aug 20;49(14):8277-8293. doi: 10.1093/nar/gkab599. Nucleic Acids Res. 2021. PMID: 34244781 Free PMC article.

7

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.

Anderson BA, Freestone GC, Low A, De-Hoyos CL, Iii WJD, Østergaard ME, Migawa MT, Fazio M, Wan WB, Berdeja A, Scandalis E, Burel SA, Vickers TA, Crooke ST, Swayze EE, Liang X, Seth PP. Anderson BA, et al. Nucleic Acids Res. 2021 Sep 20;49(16):9026-9041. doi: 10.1093/nar/gkab718. Nucleic Acids Res. 2021. PMID: 34417625 Free PMC article.

8

Insights into innate immune activation via PS-ASO-protein-TLR9 interactions.

Pollak AJ, Zhao L, Vickers TA, Huggins IJ, Liang XH, Crooke ST. Pollak AJ, et al. Among authors: liang xh. Nucleic Acids Res. 2022 Aug 12;50(14):8107-8126. doi: 10.1093/nar/gkac618. Nucleic Acids Res. 2022. PMID: 35848907 Free PMC article.

9

RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus.

Liang XH, Sun H, Nichols JG, Crooke ST. Liang XH, et al. Mol Ther. 2017 Sep 6;25(9):2075-2092. doi: 10.1016/j.ymthe.2017.06.002. Epub 2017 Jun 27. Mol Ther. 2017. PMID: 28663102 Free PMC article.

10

Antisense oligonucleotides targeting translation inhibitory elements in 5' UTRs can selectively increase protein levels.

Liang XH, Sun H, Shen W, Wang S, Yao J, Migawa MT, Bui HH, Damle SS, Riney S, Graham MJ, Crooke RM, Crooke ST. Liang XH, et al. Nucleic Acids Res. 2017 Sep 19;45(16):9528-9546. doi: 10.1093/nar/gkx632. Nucleic Acids Res. 2017. PMID: 28934489 Free PMC article.

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