Li Z - Search Results

1

Opioid Overdose: Limitations in Naloxone Reversal of Respiratory Depression and Prevention of Cardiac Arrest.

van Lemmen M, Florian J, Li Z, van Velzen M, van Dorp E, Niesters M, Sarton E, Olofsen E, van der Schrier R, Strauss DG, Dahan A. van Lemmen M, et al. Among authors: li z. Anesthesiology. 2023 Sep 1;139(3):342-353. doi: 10.1097/ALN.0000000000004622. Anesthesiology. 2023. PMID: 37402248 Free article. Review.

2

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.

Fermini B, Hancox JC, Abi-Gerges N, Bridgland-Taylor M, Chaudhary KW, Colatsky T, Correll K, Crumb W, Damiano B, Erdemli G, Gintant G, Imredy J, Koerner J, Kramer J, Levesque P, Li Z, Lindqvist A, Obejero-Paz CA, Rampe D, Sawada K, Strauss DG, Vandenberg JI. Fermini B, et al. Among authors: li z. J Biomol Screen. 2016 Jan;21(1):1-11. doi: 10.1177/1087057115594589. Epub 2015 Jul 13. J Biomol Screen. 2016. PMID: 26170255 Review.

3

Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel-Drug Binding Kinetics and Multichannel Pharmacology.

Li Z, Dutta S, Sheng J, Tran PN, Wu W, Chang K, Mdluli T, Strauss DG, Colatsky T. Li Z, et al. Circ Arrhythm Electrophysiol. 2017 Feb;10(2):e004628. doi: 10.1161/CIRCEP.116.004628. Circ Arrhythm Electrophysiol. 2017. PMID: 28202629

4

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment.

Dutta S, Chang KC, Beattie KA, Sheng J, Tran PN, Wu WW, Wu M, Strauss DG, Colatsky T, Li Z. Dutta S, et al. Among authors: li z. Front Physiol. 2017 Aug 23;8:616. doi: 10.3389/fphys.2017.00616. eCollection 2017. Front Physiol. 2017. PMID: 28878692 Free PMC article.

5

Mechanistic Model-Informed Proarrhythmic Risk Assessment of Drugs: Review of the "CiPA" Initiative and Design of a Prospective Clinical Validation Study.

Vicente J, Zusterzeel R, Johannesen L, Mason J, Sager P, Patel V, Matta MK, Li Z, Liu J, Garnett C, Stockbridge N, Zineh I, Strauss DG. Vicente J, et al. Among authors: li z. Clin Pharmacol Ther. 2018 Jan;103(1):54-66. doi: 10.1002/cpt.896. Epub 2017 Nov 16. Clin Pharmacol Ther. 2018. PMID: 28986934 Free PMC article. Review.

6

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment.

Chang KC, Dutta S, Mirams GR, Beattie KA, Sheng J, Tran PN, Wu M, Wu WW, Colatsky T, Strauss DG, Li Z. Chang KC, et al. Among authors: li z. Front Physiol. 2017 Nov 21;8:917. doi: 10.3389/fphys.2017.00917. eCollection 2017. Front Physiol. 2017. PMID: 29209226 Free PMC article.

7

Corrigendum: Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment.

Dutta S, Chang KC, Beattie KA, Sheng J, Tran PN, Wu WW, Wu M, Strauss DG, Colatsky T, Li Z. Dutta S, et al. Among authors: li z. Front Physiol. 2017 Dec 6;8:1025. doi: 10.3389/fphys.2017.01025. eCollection 2017. Front Physiol. 2017. PMID: 29230183 Free PMC article.

8

Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative.

Li Z, Ridder BJ, Han X, Wu WW, Sheng J, Tran PN, Wu M, Randolph A, Johnstone RH, Mirams GR, Kuryshev Y, Kramer J, Wu C, Crumb WJ Jr, Strauss DG. Li Z, et al. Clin Pharmacol Ther. 2019 Feb;105(2):466-475. doi: 10.1002/cpt.1184. Epub 2018 Aug 27. Clin Pharmacol Ther. 2019. PMID: 30151907 Free PMC article.

9

Comprehensive In Vitro Proarrhythmia Assay (CiPA) Update from a Cardiac Safety Research Consortium / Health and Environmental Sciences Institute / FDA Meeting.

Strauss DG, Gintant G, Li Z, Wu W, Blinova K, Vicente J, Turner JR, Sager PT. Strauss DG, et al. Among authors: li z. Ther Innov Regul Sci. 2019 Jul;53(4):519-525. doi: 10.1177/2168479018795117. Epub 2018 Aug 29. Ther Innov Regul Sci. 2019. PMID: 30157676

10

Response to "CiPA's Complexity Bias".

Li Z, Mirams GR, Strauss DG. Li Z, et al. Clin Pharmacol Ther. 2019 Jun;105(6):1325. doi: 10.1002/cpt.1399. Epub 2019 Mar 23. Clin Pharmacol Ther. 2019. PMID: 30903696 No abstract available.

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