Li XP - Search Results

1

Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.

Rudolph MJ, Dutta A, Tsymbal AM, McLaughlin JE, Chen Y, Davis SA, Theodorous SA, Pierce M, Algava B, Zhang X, Szekely Z, Roberge JY, Li XP, Tumer NE. Rudolph MJ, et al. Among authors: li xp. Bioorg Med Chem. 2024 Feb 15;100:117614. doi: 10.1016/j.bmc.2024.117614. Epub 2024 Feb 5. Bioorg Med Chem. 2024. PMID: 38340640 Free article.

2

Ribosome depurination is not sufficient for ricin-mediated cell death in Saccharomyces cerevisiae.

Li XP, Baricevic M, Saidasan H, Tumer NE. Li XP, et al. Infect Immun. 2007 Jan;75(1):417-28. doi: 10.1128/IAI.01295-06. Epub 2006 Nov 13. Infect Immun. 2007. PMID: 17101666 Free PMC article.

3

Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA.

Parikh BA, Tortora A, Li XP, Tumer NE. Parikh BA, et al. Among authors: li xp. J Biol Chem. 2008 Mar 7;283(10):6145-53. doi: 10.1074/jbc.M707981200. Epub 2008 Jan 7. J Biol Chem. 2008. PMID: 18180297 Free PMC article.

4

The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiae.

Chiou JC, Li XP, Remacha M, Ballesta JP, Tumer NE. Chiou JC, et al. Among authors: li xp. Mol Microbiol. 2008 Dec;70(6):1441-52. doi: 10.1111/j.1365-2958.2008.06492.x. Epub 2008 Oct 30. Mol Microbiol. 2008. PMID: 19019145 Free PMC article.

5

A two-step binding model proposed for the electrostatic interactions of ricin a chain with ribosomes.

Li XP, Chiou JC, Remacha M, Ballesta JP, Tumer NE. Li XP, et al. Biochemistry. 2009 May 12;48(18):3853-63. doi: 10.1021/bi802371h. Biochemistry. 2009. PMID: 19292477 Free PMC article.

6

Pentameric organization of the ribosomal stalk accelerates recruitment of ricin a chain to the ribosome for depurination.

Li XP, Grela P, Krokowski D, Tchórzewski M, Tumer NE. Li XP, et al. J Biol Chem. 2010 Dec 31;285(53):41463-71. doi: 10.1074/jbc.M110.171793. Epub 2010 Oct 25. J Biol Chem. 2010. PMID: 20974854 Free PMC article.

7

Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2.

Chiou JC, Li XP, Remacha M, Ballesta JP, Tumer NE. Chiou JC, et al. Among authors: li xp. Int J Biochem Cell Biol. 2011 Dec;43(12):1792-801. doi: 10.1016/j.biocel.2011.08.018. Epub 2011 Sep 3. Int J Biochem Cell Biol. 2011. PMID: 21907821 Free PMC article.

8

Interaction of ricin and Shiga toxins with ribosomes.

Tumer NE, Li XP. Tumer NE, et al. Among authors: li xp. Curr Top Microbiol Immunol. 2012;357:1-18. doi: 10.1007/82_2011_174. Curr Top Microbiol Immunol. 2012. PMID: 21910078 Free PMC article. Review.

9

N-glycosylation does not affect the catalytic activity of ricin a chain but stimulates cytotoxicity by promoting its transport out of the endoplasmic reticulum.

Yan Q, Li XP, Tumer NE. Yan Q, et al. Among authors: li xp. Traffic. 2012 Nov;13(11):1508-21. doi: 10.1111/j.1600-0854.2012.01404.x. Epub 2012 Sep 7. Traffic. 2012. PMID: 22882900 Free PMC article.

10

The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells.

May KL, Li XP, Martínez-Azorín F, Ballesta JP, Grela P, Tchórzewski M, Tumer NE. May KL, et al. Among authors: li xp. FEBS J. 2012 Oct;279(20):3925-36. doi: 10.1111/j.1742-4658.2012.08752.x. Epub 2012 Sep 11. FEBS J. 2012. PMID: 22909382 Free PMC article.

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