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Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine.
Imam MZ, Kuo A, Ghassabian S, Cai Y, Qin Y, Li T, Smith MT. Imam MZ, et al. Among authors: li t. Eur J Pharmacol. 2020 Mar 15;871:172918. doi: 10.1016/j.ejphar.2020.172918. Epub 2020 Jan 17. Eur J Pharmacol. 2020. PMID: 31958457
[Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.
Cai Y, Lu D, Chen Z, Ding Y, Chung NN, Li T, Schiller PW. Cai Y, et al. Among authors: li t. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3629-31. doi: 10.1016/j.bmcl.2016.06.003. Epub 2016 Jun 3. Bioorg Med Chem Lett. 2016. PMID: 27301366 Free PMC article.
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