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Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight.
Cell Metab. 2023 May 2;35(5):875-886.e5. doi: 10.1016/j.cmet.2023.03.014. Epub 2023 Apr 14.
Cell Metab. 2023.
PMID: 37060902
Free article.
Interaction of glucose sensing and leptin action in the brain.
Li RJW, Zhang SY, Lam TKT.
Li RJW, et al.
Mol Metab. 2020 Sep;39:101011. doi: 10.1016/j.molmet.2020.101011. Epub 2020 May 13.
Mol Metab. 2020.
PMID: 32416314
Free PMC article.
Review.
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FXR in the dorsal vagal complex is sufficient and necessary for upper small intestinal microbiome-mediated changes of TCDCA to alter insulin action in rats.
Zhang SY, Li RJW, Lim YM, Batchuluun B, Liu H, Waise TMZ, Lam TKT.
Zhang SY, et al. Among authors: li rjw.
Gut. 2021 Sep;70(9):1675-1683. doi: 10.1136/gutjnl-2020-321757. Epub 2020 Oct 21.
Gut. 2021.
PMID: 33087489
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Nutrient infusion in the dorsal vagal complex controls hepatic lipid and glucose metabolism in rats.
Li RJW, Batchuluun B, Zhang SY, Abraham MA, Wang B, Lim YM, Yue JTY, Lam TKT.
Li RJW, et al.
iScience. 2021 Mar 26;24(4):102366. doi: 10.1016/j.isci.2021.102366. eCollection 2021 Apr 23.
iScience. 2021.
PMID: 33870148
Free PMC article.
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A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats.
Li RJW, Chiu JFM, Bruce K, Zhang SY, Barros DR, Yue JTY, Lam TKT.
Li RJW, et al.
J Biol Chem. 2023 May;299(5):104633. doi: 10.1016/j.jbc.2023.104633. Epub 2023 Mar 23.
J Biol Chem. 2023.
PMID: 36963496
Free PMC article.
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Small intestinal CaSR-dependent and CaSR-independent protein sensing regulates feeding and glucose tolerance in rats.
Li RJW, Barros DR, Kuah R, Lim YM, Gao A, Beaudry JL, Zhang SY, Lam TKT.
Li RJW, et al.
Nat Metab. 2024 Jan;6(1):39-49. doi: 10.1038/s42255-023-00942-4. Epub 2024 Jan 2.
Nat Metab. 2024.
PMID: 38167726
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