Li L - Search Results

1

Discovery of VH domains that allosterically inhibit ENPP1.

Solomon PE, Bracken CJ, Carozza JA, Wang H, Young EP, Wellner A, Liu CC, Sweet-Cordero EA, Li L, Wells JA. Solomon PE, et al. Among authors: li l. Nat Chem Biol. 2024 Jan;20(1):30-41. doi: 10.1038/s41589-023-01368-5. Epub 2023 Jul 3. Nat Chem Biol. 2024. PMID: 37400538 Free PMC article.

2

Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.

Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Li L, et al. Nat Chem Biol. 2014 Dec;10(12):1043-8. doi: 10.1038/nchembio.1661. Epub 2014 Oct 26. Nat Chem Biol. 2014. PMID: 25344812 Free PMC article.

3

Host-Pathogen interactions: Nucleotide circles of life and death.

Li L. Li L. Nat Chem Biol. 2017 Jan 19;13(2):130-131. doi: 10.1038/nchembio.2289. Nat Chem Biol. 2017. PMID: 28103224 No abstract available.

4

Development of cGAMP-Luc, a sensitive and precise coupled enzyme assay to measure cGAMP in complex biological samples.

Mardjuki RE, Carozza JA, Li L. Mardjuki RE, et al. Among authors: li l. J Biol Chem. 2020 Apr 10;295(15):4881-4892. doi: 10.1074/jbc.RA119.012170. Epub 2020 Mar 3. J Biol Chem. 2020. PMID: 32127400 Free PMC article.

5

Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP.

Carozza JA, Brown JA, Böhnert V, Fernandez D, AlSaif Y, Mardjuki RE, Smith M, Li L. Carozza JA, et al. Among authors: li l. Cell Chem Biol. 2020 Nov 19;27(11):1347-1358.e5. doi: 10.1016/j.chembiol.2020.07.007. Epub 2020 Jul 28. Cell Chem Biol. 2020. PMID: 32726585 Free PMC article.

6

LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.

Lahey LJ, Mardjuki RE, Wen X, Hess GT, Ritchie C, Carozza JA, Böhnert V, Maduke M, Bassik MC, Li L. Lahey LJ, et al. Among authors: li l. Mol Cell. 2020 Nov 19;80(4):578-591.e5. doi: 10.1016/j.molcel.2020.10.021. Epub 2020 Nov 9. Mol Cell. 2020. PMID: 33171122 Free article.

7

Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity.

Carozza JA, Böhnert V, Nguyen KC, Skariah G, Shaw KE, Brown JA, Rafat M, von Eyben R, Graves EE, Glenn JS, Smith M, Li L. Carozza JA, et al. Among authors: li l. Nat Cancer. 2020 Feb;1(2):184-196. doi: 10.1038/s43018-020-0028-4. Epub 2020 Feb 24. Nat Cancer. 2020. PMID: 33768207 Free PMC article.

8

Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS-cGAMP-STING Pathway.

Ritchie C, Carozza JA, Li L. Ritchie C, et al. Among authors: li l. Annu Rev Biochem. 2022 Jun 21;91:599-628. doi: 10.1146/annurev-biochem-040320-101629. Epub 2022 Mar 14. Annu Rev Biochem. 2022. PMID: 35287475 Review.

9

ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling.

Carozza JA, Cordova AF, Brown JA, AlSaif Y, Böhnert V, Cao X, Mardjuki RE, Skariah G, Fernandez D, Li L. Carozza JA, et al. Among authors: li l. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2119189119. doi: 10.1073/pnas.2119189119. Epub 2022 May 19. Proc Natl Acad Sci U S A. 2022. PMID: 35588451 Free PMC article.

10

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer.

Wang S, Böhnert V, Joseph AJ, Sudaryo V, Skariah G, Swinderman JT, Yu FB, Subramanyam V, Wolf DM, Lyu X, Gilbert LA, Van't Veer LJ, Goodarzi H, Li L. Wang S, et al. Among authors: li l. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2313693120. doi: 10.1073/pnas.2313693120. Epub 2023 Dec 20. Proc Natl Acad Sci U S A. 2023. PMID: 38117852 Free PMC article.

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